CMAUP Plant Collective Molecular Activities

Plant Name: Desmodium styracifolium

Taxonomic Information:

Plant ID: NPO3292
Plant Latin Name: Desmodium styracifolium
Taxonomy Genus: Desmodium
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 648866
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia; India; Malaysia; Vietnam; China; Laos; Thailand

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Diuretic; Febrifuge; VD

Geographical Distribution:

Indonesia; India; Malaysia; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	BLM; ALOX12; HSD17B1; HSD17B2; HSD17B10; NOX4; TNKS; TNKS2; AOX1; POLB;
Hydrolase	ACHE;
Protein Kinase	PIM1; MET; FLT3; CDK1; EGFR; AXL; KDR; CDK8; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Oxidoreductase	TYR;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	AHR; TP53; HIF1A; NFKB1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP19A1; CYP2C9; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.617E-11	9.497E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.449E-11	9.497E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.088E-10	6.112E-07	CA12, CA14, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.568E-09	2.009E-06	BLM, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, TNKS, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.068E-09	2.149E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	5.121E-09	4.130E-06	ALOX12, CDK1, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, THPO, TSHR
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.750E-09	6.146E-06	ALOX12, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	4.322E-08	2.075E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.054E-07	4.251E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.449E-07	9.881E-05	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.678E-07	1.030E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0042802; identical protein binding	4.716E-07	1.208E-04	ACHE, AOX1, BLM, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NFKB1, SMN1, SMN2, TP53, TYR
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.467E-06	3.073E-04	AHR, CSNK2A1, HIF1A, KDR
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	1.683E-06	3.490E-04	AXL, CDK1, CSNK2A1, EGFR, FLT3
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.885E-06	3.836E-04	CYP19A1, CYP1A1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.385E-06	4.596E-04	CA12, CA2, CA4, CA7
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	3.110E-06	5.788E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0005488; binding	GO:0005496; steroid binding	3.110E-06	5.788E-04	ESR1, ESR2, ESRRA, ESRRB, HSD17B1
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.537E-06	6.418E-04	BLM, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NFKB1, NOX4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.751E-06	6.670E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	3.891E-06	6.779E-04	CDK1, CDK8, ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	4.868E-06	8.216E-04	CYP19A1, HSD17B1, HSD17B2
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	6.519E-06	1.051E-03	AHR, ESR1, ESR2, ESRRA, ESRRB, PIM1
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	6.835E-06	1.083E-03	ESR1, ESR2
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	8.408E-06	1.254E-03	BLM, EGFR, IGF1R, MMP2, NFKB1, NOX4, TP53, TSHR
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	8.698E-06	1.280E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0016579; protein deubiquitination	9.183E-06	1.333E-03	CDK1, ESR1, HIF1A, POLB, TNKS, TNKS2, TP53
BP	GO:0065007; biological regulation	GO:1904355; positive regulation of telomere capping	1.149E-05	1.583E-03	AURKB, TNKS, TNKS2
BP	GO:0022414; reproductive process	GO:0001892; embryonic placenta development	1.915E-05	2.383E-03	EGFR, ESRRB, HIF1A
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.047E-05	2.516E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0045944; positive regulation of transcription from RNA polymerase II promoter	2.199E-05	2.675E-03	AHR, CDK8, EGFR, ESR1, ESRRA, ESRRB, HIF1A, MET, MMP12, NFKB1, TNKS, TP53
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	2.230E-05	2.698E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.591E-05	3.066E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.959E-05	3.409E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	4.087E-05	4.378E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.087E-05	4.378E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	4.087E-05	4.378E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.087E-05	4.378E-03	CYP1A2, CYP2C9
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	4.956E-05	5.091E-03	AXL, EGFR, MET, NOX4, THPO
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	5.596E-05	5.590E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0033273; response to vitamin	6.476E-05	6.268E-03	CYP1A1, EGFR, TP53, TYR
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	7.398E-05	7.004E-03	CYP1A2, EGFR, MMP9
MF	GO:0005488; binding	GO:0042562; hormone binding	7.454E-05	7.026E-03	ACHE, EGFR, HSD17B1, IGF1R
MF	GO:0005488; binding	GO:0001047; core promoter binding	7.971E-05	7.417E-03	ESR1, ESR2, ESRRB, MMP12, TP53
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	8.197E-05	7.596E-03	CYP1B1, EGFR, HIF1A, NOX4, TP53
MF	GO:0005488; binding	GO:0005524; ATP binding	8.818E-05	8.034E-03	AURKB, AXL, BLM, CDK1, CDK8, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MET, PIM1, TP53
BP	GO:0008152; metabolic process	GO:1903580; positive regulation of ATP metabolic process	9.794E-05	8.776E-03	CDK1, ESRRB, HIF1A
BP	GO:0065007; biological regulation	GO:0032212; positive regulation of telomere maintenance via telomerase	9.794E-05	8.776E-03	AURKB, TNKS, TNKS2
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	9.901E-05	8.836E-03	AHR, AXL, CSNK2A1, EGFR, ESR1, TP53
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.075E-04	9.476E-03	ACHE, CDK1, CYP1A1, EGFR, TP53

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.015E-09	1.371E-07	MMP2, KDR, TP53, HIF1A, ESR1, MMP9, MET, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.960E-09	1.371E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.247E-08	1.428E-06	FLT3, MMP1, MMP2, HIF1A, MET, TP53, MMP9, EGFR, NFKB1, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.330E-10	7.408E-08	CA12, CA2, CA4, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.423E-09	2.579E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.164E-08	1.428E-06	MMP1, MMP2, MMP9, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.557E-07	1.501E-05	FLT3, TP53, MET, HIF1A, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.264E-06	7.317E-05	MMP2, ESR1, MMP9, EGFR, ESR2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.202E-06	4.946E-05	CYP1A2, CYP1A1, AOX1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.075E-06	3.605E-05	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	9.818E-06	1.137E-04	PIM1, CYP1B1, TP53, MMP9, MET, EGFR, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.292E-06	7.950E-05	FLT3, TP53, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	3.212E-05	2.977E-04	TP53, MET, EGFR, IGF1R
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.264E-05	2.420E-04	CYP2C9, CYP1A2, CYP1A1, AOX1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.869E-05	2.848E-04	CYP2C9, CYP1A2, AOX1, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	7.804E-05	5.709E-04	TP53, EGFR, NFKB1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.585E-05	3.093E-04	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.782E-05	3.093E-04	CSNK2A1, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.218E-04	1.468E-03	KDR, TP53, MET, EGFR, NFKB1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.364E-04	1.494E-03	CYP2C9, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALOX12, CYP2C19, TYR, CYP19A1, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.376E-04	9.566E-04	HIF1A, EGFR, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.768E-04	1.673E-03	KDR, MET, EGFR, NFKB1, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	5.616E-04	3.002E-03	THPO, FLT3, KDR, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	4.148E-04	2.402E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	6.104E-04	3.142E-03	TP53, EGFR, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.313E-04	2.954E-03	CYP2C9, ALOX12, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	6.383E-04	3.169E-03	TP53, EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.742E-03	7.062E-03	CSNK2A1, CDK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	1.261E-03	5.656E-03	CSNK2A1, CDK1, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	8.230E-04	3.813E-03	ESR1, NFKB1, ESR2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.742E-03	7.062E-03	KDR, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.838E-03	7.097E-03	POLB, CDK1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6.966E-04	3.339E-03	MET, EGFR, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.042E-03	7.670E-03	KDR, MET, EGFR, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.183E-03	7.987E-03	MMP2, PIM1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.447E-05	4.206E-04	CYP2C9, CYP1A2, CYP2C19
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.778E-03	7.062E-03	TP53, NFKB1, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.559E-03	6.770E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR; MMP2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	ESRRA;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR; CYP19A1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; TP53;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1; EGFR;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CDK1; IGF1R; KDR; FLT3; EGFR; CYP19A1;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR; MMP2;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA; EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; MMP9; EGFR; TP53; MMP2;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; EGFR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ESRRA;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; NPSR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; ESRRA; MMP2;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR; TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; ESRRA;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ESRRA; MMP1; TYR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR; MMP2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
NA: NA	Menopausal disorder	NA	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; CDK1; IGF1R; ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; EGFR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; EGFR; TP53; MMP2;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
NA: NA	Postmenopausal disorder	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA; MMP1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; FLT3; EGFR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9; EGFR; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases