Plant Name: Cynanchum auriculatum
Taxonomic Information:
Plant ID: NPO3291
Plant Latin Name: Cynanchum auriculatum
Taxonomy Genus: Cynanchum
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
157409
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 6.212E-04 | 1.000E+00 | PTPN1 |
| BP | GO:0009987; cellular process | GO:0035791; platelet-derived growth factor receptor-beta signaling pathway | 9.316E-04 | 1.000E+00 | PTPN1 |
| BP | GO:0008152; metabolic process | GO:0019371; cyclooxygenase pathway | 1.708E-03 | 1.000E+00 | PTGES |
| BP | GO:0050896; response to stimulus | GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway | 2.328E-03 | 1.000E+00 | PTPN1 |
| BP | GO:0050896; response to stimulus | GO:0046627; negative regulation of insulin receptor signaling pathway | 4.652E-03 | 1.000E+00 | PTPN1 |
| BP | Unclassified; | GO:0061098; positive regulation of protein tyrosine kinase activity | 6.664E-03 | 1.000E+00 | PTPN1 |
| BP | GO:0009987; cellular process | GO:0060338; regulation of type I interferon-mediated signaling pathway | 7.128E-03 | 1.000E+00 | PTPN1 |
| BP | GO:0032501; multicellular organismal process | GO:0030324; lung development | 1.176E-02 | 1.000E+00 | HSD11B1 |
| BP | GO:0051179; localization | GO:0030100; regulation of endocytosis | 3.363E-02 | 1.000E+00 | PTPN1 |
| BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 4.241E-02 | 1.000E+00 | PTGES |
| CC | GO:0044464; cell part | GO:0097443; sorting endosome | 9.316E-04 | 1.000E+00 | PTPN1 |
| CC | GO:0044464; cell part | GO:0005641; nuclear envelope lumen | 1.242E-03 | 1.000E+00 | PTGES |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 4.343E-03 | 1.000E+00 | PTPN1 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 8.673E-03 | 1.000E+00 | PTPN1 |
| MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 1.576E-02 | 1.000E+00 | PTPN1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 9.272E-03 | 1.633E-02 | PTGES |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.103E-02 | 1.633E-02 | HSD11B1, PTGES |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 8.675E-03 | 1.633E-02 | HSD11B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.091E-02 | 1.633E-02 | HSD11B1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.106E-02 | 1.633E-02 | PTPN1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.626E-02 | 1.858E-02 | PTPN1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.225E-02 | 1.633E-02 | HSD11B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 2.071E-02 | 2.071E-02 | PTPN1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | HSD11B1; |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1; |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
