CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	TDP1; PTGES; NOS2; ALOX15; USP2; BRCA1;
Protein Kinase	PRKCE; MAPK1; EGFR;
Lyase	CA2; CA1; CA12; CA9; CA13; CA5B; CA7; CA4; CA6;
Oxidoreductase	ALOX5; MAOA;
Aspartic protease	BACE1;
Metallo protease	MMP9; ANPEP;
Toll-like and Il-1 receptors	TLR9;
Transcription Factor	HIF1A;
Bromodomain	EP300;
SLC superfamily of solute carriers	SLC22A8; SLC22A6;
Unclassified	HTT; NFE2L2; LMNA; F3; MAPT; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	NOS2	Nitric oxide synthase, inducible	P35228	CHEMBL4481
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	5.392E-07	4.048E-04	APP, EGFR, MAPT
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.826E-06	1.053E-03	CA2, CA7, PRKCE
BP	GO:0009987; cellular process	GO:2001234; negative regulation of apoptotic signaling pathway	2.773E-06	1.244E-03	BRCA1, HIF1A, HTT, LMNA, MMP9, NFE2L2
BP	GO:0007610; behavior	GO:0007611; learning or memory	5.158E-06	2.006E-03	APP, EGFR, HIF1A, HTT, MAPK1, MAPT
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	6.958E-06	2.612E-03	APP, BRCA1, CA2, CA9, EGFR, MAPK1, PRKCE, PTGES, SLC22A6
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	9.552E-06	3.152E-03	APP, CA2, CA7, HIF1A, HTT, MAPK1, NPSR1, PRKCE
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.070E-05	3.368E-03	CA2, CA7
BP	GO:0050896; response to stimulus	GO:0043627; response to estrogen	1.128E-05	3.432E-03	BRCA1, CA2, EP300, MAPK1
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	1.459E-05	3.922E-03	BRCA1, EGFR, MAPK1, NFE2L2, NOS2, PRKCE
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	1.741E-05	4.351E-03	ALOX15, BRCA1, HIF1A, HTT, MAPK1, MAPT, MMP9, PRKCE

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.126E-21	3.167E-19	CA12, CA1, CA5B, CA2, CA4, CA7, CA6, CA9, CA13
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	5.120E-06	1.907E-04	CYP2C9, ALOX5, ALOX15, PTGES
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.310E-03	8.706E-03	CYP2C9, ALOX15
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.256E-06	6.239E-05	NOS2, EP300, MAPK1, HIF1A, EGFR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	3.451E-04	4.286E-03	EP300, MAPK1, EGFR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.438E-08	4.051E-06	CYP2C9, APP, MAOA, ALOX5, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	8.090E-04	7.097E-03	MAPK1, MMP9, EGFR
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.344E-03	8.706E-03	EP300, MAPK1, HIF1A
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	8.221E-04	7.097E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.609E-05	4.795E-04	PRKCE, EP300, MAPK1, BRCA1, MMP9, EGFR

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Jacobaea maritima

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities