Plant Name: tabernaemontana calcarea
Taxonomic Information:
Plant ID: NPO32495
Plant Latin Name: tabernaemontana calcarea
Taxonomy Genus: Tabernaemontana
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
761054
Plant-of-the-World-Online:
82035-1
Used in Medicines:
Unknown.
Geographical Distribution:
Madagascar
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0050968; detection of chemical stimulus involved in sensory perception of pain | 3.106E-04 | 1.000E+00 | TRPA1 |
| BP | GO:0032501; multicellular organismal process | GO:0050955; thermoception | 3.106E-04 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:0038003; opioid receptor signaling pathway | 8.282E-04 | 1.000E+00 | SIGMAR1 |
| BP | GO:0032501; multicellular organismal process | GO:0050966; detection of mechanical stimulus involved in sensory perception of pain | 1.035E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0032501; multicellular organismal process | GO:0048265; response to pain | 1.656E-03 | 1.000E+00 | TRPA1 |
| BP | Unclassified; | GO:0006461; protein complex assembly | 3.199E-03 | 1.000E+00 | SIGMAR1, TRPA1 |
| BP | GO:0051179; localization | GO:0051209; release of sequestered calcium ion into cytosol | 4.654E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:0051289; protein homotetramerization | 7.648E-03 | 1.000E+00 | TRPA1 |
| BP | GO:0050896; response to stimulus | GO:0042542; response to hydrogen peroxide | 1.115E-02 | 1.000E+00 | TRPA1 |
| BP | GO:0009987; cellular process | GO:0043523; regulation of neuron apoptotic process | 1.999E-02 | 1.000E+00 | SIGMAR1 |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 2.142E-02 | 1.000E+00 | TRPA1 |
| BP | GO:0051179; localization | GO:0006869; lipid transport | 2.746E-02 | 1.000E+00 | SIGMAR1 |
| BP | GO:0032501; multicellular organismal process | GO:0007399; nervous system development | 3.327E-02 | 1.000E+00 | SIGMAR1 |
| BP | GO:0051179; localization | GO:0006810; transport | 4.461E-02 | 1.000E+00 | SIGMAR1, TRPA1 |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 5.177E-04 | 1.000E+00 | TRPA1 |
| CC | GO:0044425; membrane part | GO:0005887; integral component of plasma membrane | 5.317E-03 | 1.000E+00 | SIGMAR1, TRPA1 |
| CC | GO:0043226; organelle | GO:0014069; postsynaptic density | 2.040E-02 | 1.000E+00 | SIGMAR1 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 2.173E-02 | 1.000E+00 | SIGMAR1 |
| MF | GO:0060089; molecular transducer activity | GO:0004985; opioid receptor activity | 8.282E-04 | 1.000E+00 | SIGMAR1 |
| MF | GO:0005215; transporter activity | GO:0015278; calcium-release channel activity | 1.863E-03 | 1.000E+00 | TRPA1 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 3.418E-02 | 1.000E+00 | TRPA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 9.776E-03 | 9.776E-03 | TRPA1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
