CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; BLM; RECQL; ALOX15; HSD17B10;
Protein Kinase	PIM1; CSNK2A1; MAPK1;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Serine protease	ELANE;
Transcription Factor	HIF1A;
Unclassified	MAPT; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.304E-05	3.034E-02	CSNK2A1, ELANE, ESR1, HIF1A, MAPK1, PIM1, TSHR
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.372E-05	3.034E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0034641; cellular nitrogen compound metabolic process	1.533E-05	3.034E-02	BLM, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, HIF1A, HSD17B10, MAPK1, RECQL, SMN1, SMN2, TDP1
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	3.286E-05	3.253E-02	HIF1A, MAPT
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	3.286E-05	3.253E-02	BLM, RECQL
CC	GO:0044464; cell part	GO:0005737; cytoplasm	1.503E-05	3.034E-02	BLM, CYP3A4, ELANE, ESR1, HIF1A, HSD17B10, MAPK1, MAPT, PIM1, RECQL, SMN1, SMN2, TDP1
CC	GO:0043226; organelle	GO:0043229; intracellular organelle	2.439E-05	3.253E-02	ALOX15, BLM, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, HIF1A, HSD17B10, LMNA, MAPK1, MAPT, PIM1, RECQL, SMN1, SMN2, TDP1
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.714E-05	3.517E-02	HIF1A, MAPK1, MAPT
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.015E-05	4.225E-02	SMN1, SMN2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	9.167E-07	1.996E-02	ESR1, ESR2

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	3.085E-04	CYP2C9, ALOX15, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.716E-03	1.628E-02	CYP2C9, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	4.159E-05	2.454E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.076E-04	4.233E-03	MAPK1, ESR1, ESR2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.552E-04	4.273E-03	CYP2C9, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.811E-04	4.273E-03	MAPK1, ESR1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	8.855E-04	1.493E-02	MAPK1, HIF1A, ESR1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	5.110E-04	1.005E-02	MAPK1, MAPT, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.769E-03	1.628E-02	MAPK1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.822E-03	1.628E-02	MAPK1, HIF1A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: rumex plants

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities