Plant Name: rumex plants
Taxonomic Information:
Plant ID: NPO32491
Plant Latin Name: rumex plants
Taxonomy Genus: Rumex
Taxonomy Family: Polygonaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| TDP1; BLM; RECQL; ALOX15; HSD17B10; | |
| PIM1; CSNK2A1; MAPK1; | |
| ESR1; ESR2; | |
| ELANE; | |
| HIF1A; | |
| MAPT; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 9.167E-07 | 1.996E-02 | ESR1, ESR2 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 3.930E-06 | 2.392E-02 | CSNK2A1, HIF1A, MAPT |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 5.494E-06 | 2.392E-02 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 5.494E-06 | 2.392E-02 | CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 9.151E-06 | 2.846E-02 | BLM, RECQL |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 1.304E-05 | 3.034E-02 | CSNK2A1, ELANE, ESR1, HIF1A, MAPK1, PIM1, TSHR |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.372E-05 | 3.034E-02 | CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0034641; cellular nitrogen compound metabolic process | 1.533E-05 | 3.034E-02 | BLM, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, HIF1A, HSD17B10, MAPK1, RECQL, SMN1, SMN2, TDP1 |
| CC | GO:0044464; cell part | GO:0005737; cytoplasm | 1.503E-05 | 3.034E-02 | BLM, CYP3A4, ELANE, ESR1, HIF1A, HSD17B10, MAPK1, MAPT, PIM1, RECQL, SMN1, SMN2, TDP1 |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 3.286E-05 | 3.253E-02 | HIF1A, MAPT |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 3.286E-05 | 3.253E-02 | BLM, RECQL |
| CC | GO:0043226; organelle | GO:0043229; intracellular organelle | 2.439E-05 | 3.253E-02 | ALOX15, BLM, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, HIF1A, HSD17B10, LMNA, MAPK1, MAPT, PIM1, RECQL, SMN1, SMN2, TDP1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 3.714E-05 | 3.517E-02 | HIF1A, MAPK1, MAPT |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 6.015E-05 | 4.225E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.615E-06 | 3.085E-04 | CYP2C9, ALOX15, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 4.159E-05 | 2.454E-03 | MAPK1, ESR1, ESR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 1.076E-04 | 4.233E-03 | MAPK1, ESR1, ESR2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.552E-04 | 4.273E-03 | CYP2C9, ALOX15, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.811E-04 | 4.273E-03 | MAPK1, ESR1, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 8.855E-04 | 1.493E-02 | MAPK1, HIF1A, ESR1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 5.110E-04 | 1.005E-02 | MAPK1, MAPT, HSD17B10 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.769E-03 | 1.628E-02 | MAPK1, HIF1A |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.716E-03 | 1.628E-02 | CYP2C9, CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.822E-03 | 1.628E-02 | MAPK1, HIF1A |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
