Plant Name: gardenia urvillei
Taxonomic Information:
Plant ID: NPO32456
Plant Latin Name: gardenia urvillei
Taxonomy Genus: Gardenia
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2D6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 3.216E-08 | 7.004E-04 | APEX1, POLB |
| MF | Unclassified; | GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity | 2.507E-06 | 1.365E-02 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:0070988; demethylation | 5.482E-05 | 1.985E-01 | APEX1, CYP2D6 |
| BP | GO:0009987; cellular process | GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage | 7.294E-05 | 1.985E-01 | MCL1, POLB |
| MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 7.080E-05 | 1.985E-01 | APEX1, POLB |
| CC | GO:0044464; cell part | GO:0005739; mitochondrion | 1.135E-03 | 6.732E-01 | APEX1, CYP2D6, MCL1 |
| CC | GO:0032991; macromolecular complex | GO:0097136; Bcl-2 family protein complex | 1.242E-03 | 6.732E-01 | MCL1 |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 1.093E-02 | 1.000E+00 | POLB |
| CC | GO:0043226; organelle | GO:0000784; nuclear chromosome, telomeric region | 2.686E-02 | 1.000E+00 | APEX1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.581E-05 | 1.581E-04 | POLB, APEX1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 4.840E-02 | CYP2D6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.452E-02 | 4.840E-02 | CYP2D6 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.221E-02 | 5.205E-02 | CYP2D6 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 5.205E-02 | MCL1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 3.123E-02 | 5.205E-02 | MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 4.038E-02 | 5.768E-02 | POLB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 5.061E-02 | 6.327E-02 | POLB |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 6.648E-02 | 6.648E-02 | MCL1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 5.809E-02 | 6.455E-02 | MCL1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
