CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	APEX1; POLB;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Showing 1 to 4 of 4 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	3.216E-08	7.004E-04	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0070988; demethylation	5.482E-05	1.985E-01	APEX1, CYP2D6
BP	GO:0009987; cellular process	GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage	7.294E-05	1.985E-01	MCL1, POLB
CC	GO:0044464; cell part	GO:0005739; mitochondrion	1.135E-03	6.732E-01	APEX1, CYP2D6, MCL1
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	1.242E-03	6.732E-01	MCL1
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	1.093E-02	1.000E+00	POLB
CC	GO:0043226; organelle	GO:0000784; nuclear chromosome, telomeric region	2.686E-02	1.000E+00	APEX1
MF	Unclassified;	GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity	2.507E-06	1.365E-02	APEX1, POLB
MF	GO:0005488; binding	GO:0003684; damaged DNA binding	7.080E-05	1.985E-01	APEX1, POLB

Showing 1 to 9 of 9 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.373E-02	4.840E-02	CYP2D6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.452E-02	4.840E-02	CYP2D6
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.581E-05	1.581E-04	POLB, APEX1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	3.123E-02	5.205E-02	MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	6.648E-02	6.648E-02	MCL1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	5.205E-02	MCL1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.221E-02	5.205E-02	CYP2D6
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	4.038E-02	5.768E-02	POLB
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	5.061E-02	6.327E-02	POLB
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	5.809E-02	6.455E-02	MCL1

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: gardenia urvillei

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities