CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Transient receptor potential channel	TRPA1;
Enzyme_unclassified	ADK; ALOX15; HPGD; ALDH1A1;
Transcription Factor	STAT6;
SLC superfamily of solute carriers	SLC28A2; SLC28A1; SLC28A3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC28A2	Sodium/nucleoside cotransporter 2	O43868	CHEMBL5780
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251

Showing 1 to 10 of 13 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.539E-08	7.899E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	4.878E-07	9.657E-04	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	1.463E-06	1.770E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	1.463E-06	1.770E-03	SLC28A1, SLC28A3
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	7.305E-06	6.964E-03	ALOX15, HPGD
BP	GO:0051179; localization	GO:0006909; phagocytosis	1.012E-05	8.904E-03	ADORA1, ADORA2A, ALOX15
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.463E-06	1.770E-03	ADORA1, ADORA2A
CC	GO:0044456; synapse part	GO:0099055; integral component of postsynaptic membrane	1.751E-05	1.192E-02	ADORA1, ADORA2A
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.353E-05	1.464E-02	ADORA1, ADORA2A, ADORA3, SLC28A1, SLC28A2, SLC28A3, TRPA1
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	3.206E-05	1.887E-02	SMN1, SMN2

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.012E-02	8.047E-02	ALOX15
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.255E-02	9.723E-02	ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.457E-02	9.723E-02	ALDH1A1
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	6.252E-03	3.751E-02	SMN2, SMN1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.543E-04	2.050E-02	ADORA2A, ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.099E-03	3.719E-02	ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	5.905E-03	3.751E-02	ADORA3, ADORA1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	8.286E-03	3.977E-02	ADORA2A, ADORA1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.851E-02	9.723E-02	ADORA1
09150 Organismal Systems	09152 Endocrine system	hsa04924	Renin secretion	4.389E-02	9.723E-02	ADORA1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;

Showing 1 to 10 of 39 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Loranthus parasiticus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities