CMAUP Plant Collective Molecular Activities

Plant Name: Amomum kravanh

Taxonomic Information:

Plant ID: NPO31457
Plant Latin Name: Amomum kravanh
Taxonomy Genus: Amomum
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA7; CA4; CA6; CA12; CA9; CA14;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.501E-07	2.515E-04	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.061E-06	1.359E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	5.300E-06	6.074E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.628E-24	1.443E-19	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.816E-19	1.977E-15	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.303E-17	1.438E-13	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	1.588E-05	1.729E-02	CA2, CA7
BP	GO:0065007; biological regulation	GO:0030641; regulation of cellular pH	2.455E-05	2.546E-02	CA2, CA7, MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.895E-23	1.876E-21	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	8.291E-05	4.104E-03	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	3.310E-02	9.814E-02	MAPK1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3.310E-02	9.814E-02	GAA
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	3.542E-02	9.814E-02	MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	3.542E-02	9.814E-02	MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	3.600E-02	9.814E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.832E-02	9.814E-02	MAPK1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	3.368E-02	9.814E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	3.658E-02	9.814E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases