Plant Name: Scutellaria balcalensis
Taxonomic Information:
Plant ID: NPO31378
Plant Latin Name: Scutellaria balcalensis
Taxonomy Genus: Scutellaria
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GLA; ALOX15; AKR1B1; | |
| FLT3; MAPK1; | |
| PPARD; PPARA; | |
| TLR2; | |
| FABP3; CREB1; FABP2; FABP4; RAB9A; NPC1; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | GLA | Alpha-galactosidase A | P06280 | CHEMBL2524 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | CREB1 | Cyclic AMP-responsive element-binding protein 1 | P16220 | CHEMBL5587 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 6.595E-09 | 2.051E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.357E-08 | 3.236E-05 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 6.716E-08 | 1.125E-04 | AKR1B1, CYP2C19, CYP2C9, CYP3A4, NPC1, PPARD |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.487E-07 | 2.024E-04 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.993E-06 | 2.229E-03 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0045834; positive regulation of lipid metabolic process | 4.471E-06 | 2.434E-03 | CREB1, FABP3, FLT3, PPARA |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 4.916E-06 | 2.489E-03 | CYP2C9, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0071248; cellular response to metal ion | 9.314E-06 | 4.359E-03 | ALOX15, CREB1, FABP4, MAPK1 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 9.408E-06 | 4.359E-03 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.267E-05 | 5.632E-03 | ALOX15, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0071345; cellular response to cytokine stimulus | 1.434E-05 | 6.124E-03 | ALOX15, CREB1, FABP4, FLT3, MAPK1 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 4.489E-05 | 1.465E-02 | FABP3, PPARD |
| CC | GO:0044464; cell part | GO:0035578; azurophil granule lumen | 7.842E-05 | 2.372E-02 | FABP5, GLA, MAPK1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.036E-04 | 2.724E-02 | AKR1B1, GLA, NPC1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.425E-11 | 3.299E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.075E-08 | 7.312E-07 | CYP2C9, ALOX15, CYP3A4, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.684E-06 | 1.217E-04 | CYP2C9, ALOX15, MAPK1, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.737E-05 | 5.907E-04 | FLT3, MAPK1, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.239E-05 | 6.091E-04 | CYP2C9, ALOX15, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 3.090E-05 | 7.004E-04 | CYP2C9, CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.185E-05 | 1.007E-03 | CYP2C9, CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.869E-04 | 4.878E-03 | CREB1, MAPK1, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 7.092E-04 | 8.768E-03 | CREB1, MAPK1, PPARA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 5.126E-04 | 6.972E-03 | CREB1, MAPK1, TLR2 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 3.279E-04 | 4.954E-03 | AKR1B1, GLA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
