CMAUP Plant Collective Molecular Activities

Plant Name: Stephania cepharantha

Taxonomic Information:

Plant ID: NPO31374
Plant Latin Name: Stephania cepharantha
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 152367
Plant-of-the-World-Online: 581404-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Taiwan; Vietnam; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Phosphodiesterase 10	PDE10A;
Phosphodiesterase 3	PDE3B; PDE3A;
Phosphodiesterase 2	PDE2A;
Phosphodiesterase 5	PDE5A;
Enzyme_unclassified	GLA; TDP1; BLM; ALOX12; ALDH1A1; USP2;
Potassium channels	KCNH2;
Protein Kinase	MAPK1;
Transcription Factor	HIF1A; NFKB1;
Bromodomain	CREBBP;
Unclassified	LMNA; NPC1; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GLA	Alpha-galactosidase A	P06280	CHEMBL2524
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Phosphodiesterase 10	PDE10A	Phosphodiesterase 10A	Q9Y233	CHEMBL4409
Phosphodiesterase 2	PDE2A	Phosphodiesterase 2A	O00408	CHEMBL2652
Phosphodiesterase 3	PDE3B	Phosphodiesterase 3B	Q13370	CHEMBL290
Phosphodiesterase 3	PDE3A	Phosphodiesterase 3A	Q14432	CHEMBL241
Phosphodiesterase 5	PDE5A	Phosphodiesterase 5A	O76074	CHEMBL1827
Potassium channels	KCNH2	HERG	Q12809	CHEMBL240
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0047555; 3',5'-cyclic-GMP phosphodiesterase activity	3.771E-12	8.212E-08	PDE10A, PDE2A, PDE3A, PDE3B, PDE5A
BP	GO:0008152; metabolic process	GO:0006198; cAMP catabolic process	1.819E-09	4.401E-06	PDE10A, PDE2A, PDE3A, PDE3B
MF	GO:0003824; catalytic activity	GO:0004115; 3',5'-cyclic-AMP phosphodiesterase activity	2.479E-09	5.397E-06	PDE10A, PDE2A, PDE3A, PDE3B
BP	GO:0008152; metabolic process	GO:0046069; cGMP catabolic process	3.362E-08	4.881E-05	PDE10A, PDE2A, PDE5A
MF	GO:0005488; binding	GO:0030553; cGMP binding	7.593E-07	6.614E-04	PDE10A, PDE2A, PDE5A
MF	GO:0003824; catalytic activity	GO:0004119; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	1.480E-06	1.151E-03	PDE3A, PDE3B
MF	GO:0005488; binding	GO:0030552; cAMP binding	2.936E-06	2.131E-03	PDE10A, PDE2A, PDE3A
MF	GO:0003824; catalytic activity	GO:0004118; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	4.435E-06	2.567E-03	PDE10A, PDE2A
BP	GO:0009987; cellular process	GO:0060282; positive regulation of oocyte development	8.864E-06	4.289E-03	PDE3A, PDE5A
MF	GO:0005488; binding	GO:0042802; identical protein binding	1.159E-05	4.904E-03	BLM, GLA, KCNH2, MAPK1, MAPT, NFKB1, PDE2A, SMN1, SMN2, USP2
CC	GO:0044464; cell part	GO:0043204; perikaryon	1.155E-05	4.904E-03	MAPK1, PDE10A, SMN1, SMN2
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.833E-05	6.881E-03	BLM, CREBBP, HIF1A, LMNA, MAPT, NFKB1, PDE2A, USP2
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	2.167E-05	7.752E-03	BLM, KCNH2, MAPK1, NFKB1, PDE2A
BP	GO:0050896; response to stimulus	GO:0071321; cellular response to cGMP	2.213E-05	7.752E-03	PDE2A, PDE3A
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.213E-05	7.752E-03	CYP2C19, CYP3A4
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	7.663E-05	1.963E-02	HIF1A, MAPK1, MAPT
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	9.691E-05	2.305E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.144E-04	2.623E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.043E-07	1.471E-05	CREBBP, PDE3B, PDE3A, MAPK1, NFKB1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.429E-06	8.696E-05	PDE2A, PDE3B, PDE3A, MAPK1, PDE5A
09100 Metabolism	09104 Nucleotide metabolism	hsa00230	Purine metabolism	1.850E-06	8.696E-05	PDE10A, PDE2A, PDE3B, PDE3A, PDE5A
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	3.974E-06	1.401E-04	PDE10A, PDE3B, PDE2A, PDE3A
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	6.512E-06	1.836E-04	CREBBP, MAPK1, HIF1A, NFKB1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	6.611E-05	1.554E-03	CREBBP, MAPK1, HIF1A
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.611E-04	3.246E-03	CREBBP, MAPK1, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.176E-04	5.597E-03	MAPK1, ALOX12, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.702E-04	5.799E-03	CREBBP, MAPK1, HIF1A
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.101E-04	7.820E-03	LMNA, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	6.893E-04	8.099E-03	CREBBP, MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.493E-04	7.745E-03	CYP3A4, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	PDE10A;
NA: NA	Schizoaffective disorder	NA	PDE10A;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	PDE10A;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases