CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL; AKR1B10; AKR1B1;
Lyase	CA12; CA9;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2A13; CYP2A6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.565E-09	3.882E-05	AKR1B1, AKR1B10, APP, CYP1A2, CYP2A6, NR1H4
BP	GO:0008152; metabolic process	GO:0044281; small molecule metabolic process	5.891E-08	3.207E-04	AKR1B1, AKR1B10, APP, CA12, CA9, CYP1A2, CYP2A13, CYP2A6, NR1H4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.421E-07	1.054E-03	CYP1A2, CYP2A13, CYP2A6
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	3.530E-08	2.562E-04	APP, CA12, CA9, CYP1A2, CYP2A13, CYP2A6, NR1H4, RORC
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	3.538E-07	1.284E-03	CYP2A13, CYP2A6
MF	GO:0003824; catalytic activity	GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	4.725E-07	1.470E-03	CYP1A2, CYP2A13, CYP2A6

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.464E-18	6.384E-16	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.566E-10	1.120E-08	HSD11B1, CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.423E-09	1.837E-07	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.652E-09	1.306E-07	CYP2C9, PLA2G1B, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.403E-07	5.727E-06	CYP2C9, CYP2A6, CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.988E-04	2.848E-03	CYP2C9, PLA2G1B, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.452E-04	2.504E-03	HSD11B1, CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.288E-05	5.574E-04	CYP2A6, CYP1A2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.737E-05	2.912E-04	PTPN1, MAPK1, ACP1, PTPRF
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.630E-06	7.416E-05	CYP2C9, APP, CYP2D6, MAPK1, CYP2C19

Showing 1 to 10 of 19 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	APP; CDC25B; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Glioma	C71	APP;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;

Showing 1 to 10 of 26 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aralia continentalis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities