Plant ID: NPO3113
Plant Latin Name: Xyris semifuscata
Taxonomy Genus: Xyris
Taxonomy Family: Xyridaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
GPBAR1; | |
PTPN1; PTPN2; CDC25B; | |
PLA2G1B; AKR1B10; POLB; | |
NR1H4; | |
SLCO1B3; SLCO1B1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 4.027E-07 | 3.938E-03 | NR1H4, SLCO1B1, SLCO1B3 |
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 7.235E-07 | 3.938E-03 | GPBAR1, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 7.235E-07 | 3.938E-03 | GPBAR1, NR1H4 |
BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.447E-06 | 6.300E-03 | PTPN1, PTPN2 |
BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.818E-06 | 6.598E-03 | NR1H4, PTPN1, PTPN2 |
BP | GO:0008152; metabolic process | GO:0016311; dephosphorylation | 8.961E-06 | 1.626E-02 | CDC25B, POLB, PTPN1, PTPN2 |
MF | GO:0005488; binding | GO:0032052; bile acid binding | 8.667E-06 | 1.626E-02 | NR1H4, PLA2G1B |
MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 1.670E-05 | 2.424E-02 | CDC25B, PTPN1, PTPN2 |
MF | GO:0005215; transporter activity | GO:0015125; bile acid transmembrane transporter activity | 3.675E-05 | 4.445E-02 | SLCO1B1, SLCO1B3 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 5.054E-06 | 1.314E-04 | SLCO1B1, SLCO1B3, NR1H4 |
09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 1.243E-02 | 6.436E-02 | PLA2G1B |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.441E-02 | 6.436E-02 | PLA2G1B |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.490E-02 | 6.436E-02 | AKR1B10 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.786E-02 | 6.436E-02 | AKR1B10 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.589E-02 | 6.436E-02 | AKR1B10 |
09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 2.032E-02 | 6.436E-02 | PLA2G1B |
09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 2.912E-02 | 7.228E-02 | AKR1B10 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.638E-02 | 6.436E-02 | POLB |
09100 Metabolism | 09103 Lipid metabolism | hsa00565 | Ether lipid metabolism | 2.228E-02 | 6.436E-02 | PLA2G1B |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |