Plant Name: Cassia siamea
Taxonomic Information:
Plant ID: NPO31100
Plant Latin Name: Cassia siamea
Taxonomy Genus: Cassia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038194; thyroid-stimulating hormone signaling pathway | 2.071E-04 | 5.010E-01 | TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 2.071E-04 | 5.010E-01 | TSHR |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 9.317E-04 | 8.115E-01 | MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 9.317E-04 | 8.115E-01 | MAPT |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.139E-03 | 8.855E-01 | MAPT |
| CC | GO:0044464; cell part | GO:0036464; cytoplasmic ribonucleoprotein granule | 1.906E-02 | 1.000E+00 | MAPT |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.917E-02 | 1.000E+00 | TSHR |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 2.897E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 3.311E-03 | 1.000E+00 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 5.293E-03 | 1.654E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 5.592E-03 | 1.654E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 7.088E-03 | 1.654E-02 | TSHR |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.673E-02 | 2.751E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.980E-02 | 2.751E-02 | TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 2.534E-02 | 2.751E-02 | MAPT |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.751E-02 | 2.751E-02 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
