CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; HSD17B10;
Protein Phosphatase	PTPN1;
Lyase	CA2; CA3; CA14; CA7; CA6; CA12; CA1; CA9; CA5A; CA5B;
Metallo protease	MMP2; MMP9; MMP1;
Transcription Factor	NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594

Showing 1 to 10 of 18 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.459E-06	3.150E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.392E-23	5.871E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.395E-21	2.393E-17	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	2.863E-05	2.710E-02	MMP1, MMP2, MMP9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.675E-05	3.334E-02	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.598E-29	1.437E-24	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	8.352E-15	2.598E-11	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PTPN1
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.228E-05	1.273E-02	CA1, CA2

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.015E-28	2.201E-26	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	4.330E-03	4.516E-02	MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.916E-03	5.475E-02	LMNA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.524E-03	4.516E-02	MMP2, MMP9
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	4.965E-03	4.530E-02	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.387E-06	2.331E-04	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.753E-04	9.132E-03	MMP1, MMP2, MMP9, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3.665E-03	4.516E-02	MMP2, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	4.254E-03	4.516E-02	PTPN1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.500E-03	5.475E-02	MMP9, NFKB1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;

Showing 1 to 10 of 16 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Pulsatilla koreana

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities