Plant ID: NPO31026
Plant Latin Name: Myrica rubra
Taxonomy Genus: Myrica
Taxonomy Family: Myricaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Astringent; Cardiac; Carminative; Pectoral; Skin; Stomachic; Vulnerary
China
TDP1; RECQL; TERT; GLO1; PGD; AKR1B10; POLB; APEX1; | |
ACHE; | |
BCL2; | |
TOP2A; | |
NR1H4; | |
KDM4E; | |
FUT7; | |
DNMT1; | |
ABCB1; | |
L3MBTL1; | |
LMNA; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
Enzyme_unclassified | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Transferase | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Q11130 | CHEMBL3596077 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0006725; cellular aromatic compound metabolic process | 2.085E-07 | 1.513E-03 | ACHE, AKR1B10, APEX1, BCL2, CYP1A1, CYP1B1, DNMT1, KDM4E, L3MBTL1, NR1H4, PGD, POLB, RECQL, TDP1, TERT, TOP2A |
BP | GO:0008152; metabolic process | GO:0006081; cellular aldehyde metabolic process | 5.433E-07 | 2.064E-03 | AKR1B10, CYP1B1, GLO1, PGD |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 1.019E-06 | 3.168E-03 | APEX1, POLB |
BP | GO:0019740; nitrogen utilization | GO:0006808; regulation of nitrogen utilization | 3.054E-06 | 6.209E-03 | BCL2, NR1H4 |
BP | GO:0032502; developmental process | GO:0007568; aging | 3.137E-06 | 6.209E-03 | APEX1, BCL2, CYP1A1, POLB, TERT |
BP | GO:0008152; metabolic process | GO:0034641; cellular nitrogen compound metabolic process | 5.183E-06 | 9.405E-03 | ACHE, APEX1, CYP1B1, DNMT1, FUT7, GLO1, KDM4E, L3MBTL1, NR1H4, PGD, POLB, RECQL, TDP1, TERT, TOP2A |
BP | GO:0009987; cellular process | GO:1900087; positive regulation of G1/S transition of mitotic cell cycle | 6.631E-06 | 9.627E-03 | APEX1, CYP1A1, TERT |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 1.914E-04 | 9.377E-03 | DNMT1, ABCB1, BCL2, CYP1B1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |
C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | DNMT1; |
C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | TOP2A; ABCB1; |
C00-D49: Neoplasms | Soft tissue sarcoma | C00-D49 | DNMT1; |
C00-D49: Neoplasms | Glioblastoma multiforme | C71 | DNMT1; |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; |
C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | DNMT1; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
C00-D49: Neoplasms | Ocular cancer | C69 | APEX1; |
L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
C00-D49: Neoplasms | Tumors | C00-D48 | TERT; |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
C00-D49: Neoplasms | Melanoma | C43 | TERT; |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
NA: NA | Upper abdominal bloating | NA | ACHE; |
H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; |
C00-D49: Neoplasms | Prostate cancer | C61 | TERT; BCL2; |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; ABCB1; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
C00-D49: Neoplasms | Liver cancer | C22 | TERT; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
C00-D49: Neoplasms | Breast cancer | C50 | TERT; BCL2; |
C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; |
C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1; |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
C00-D49: Neoplasms | Cancer | C00-C96 | ACHE; DNMT1; ABCB1; BCL2; |
C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; BCL2; |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; DNMT1; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | DNMT1; ABCB1; |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |