CMAUP Plant Collective Molecular Activities

Plant Name: Arachniodes exilis

Taxonomic Information:

Plant ID: NPO3102
Plant Latin Name: Arachniodes exilis
Taxonomy Genus: Arachniodes
Taxonomy Family: Dryopteridaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	CDC25B;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	STAT3; TP53;
Unclassified	KLF5; FABP3; FABP2; FABP4; GMNN; LMNA; FABP5;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	KLF5	Kruppel-like factor 5	Q13887	CHEMBL1293249
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.306E-09	3.182E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.042E-08	3.242E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	1.383E-08	3.346E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP5, KLF5, LMNA, PPARA, PPARD, SMN1, SMN2, STAT3, TLR2, TP53, TSHR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.134E-07	1.319E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.212E-07	1.319E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.248E-06	9.367E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.659E-06	1.095E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009299; mRNA transcription	2.152E-06	1.266E-03	PPARD, STAT3, TP53
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	4.244E-06	2.100E-03	CYP1B1, FABP3, LMNA, PPARD, STAT3, TLR2, TP53
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	5.247E-06	2.380E-03	CYP1A1, CYP1A2, CYP1B1, KLF5, STAT3, TLR2, TP53
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.104E-06	2.712E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0020037; heme binding	8.209E-06	3.438E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	1.572E-05	6.067E-03	CYP1A1, CYP1B1, FABP4, KLF5, PPARD, STAT3, TP53, TSHR
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.697E-05	6.241E-03	PPARA, PPARD, STAT3
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.981E-05	6.847E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	2.132E-05	7.143E-03	PPARA, TP53
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.841E-05	9.234E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0070491; repressing transcription factor binding	3.128E-05	9.731E-03	GMNN, PPARA, STAT3
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	5.657E-05	1.579E-02	CDC25B, FABP5, GMNN, KLF5, LMNA, PPARA, PPARD, SMN1, SMN2, STAT3, TP53
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	6.681E-05	1.753E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	7.890E-05	1.997E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	1.543E-04	3.200E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	5.037E-11	4.080E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.979E-07	1.207E-05	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	8.252E-06	2.228E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.627E-05	3.294E-04	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.086E-05	8.240E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.914E-04	2.214E-03	STAT3, CYP1B1, TP53, CDC25B
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.201E-05	9.721E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	3.017E-04	2.899E-03	STAT3, PPARA, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	3.966E-04	3.213E-03	STAT3, TP53, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.221E-04	2.899E-03	STAT3, TP53, TLR2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.034E-03	7.614E-03	STAT3, TP53, TLR2
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.467E-03	9.141E-03	STAT3, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.416E-03	9.141E-03	FABP4, TSHR
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	1.903E-03	9.928E-03	STAT3, TLR2
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.961E-03	9.928E-03	STAT3, TP53
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.903E-03	9.928E-03	CYP1A2, CYP1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases