Plant Name: Pycnarrhena ozantha
Taxonomic Information:
Plant ID: NPO3092
Plant Latin Name: Pycnarrhena ozantha
Taxonomy Genus: Pycnarrhena
Taxonomy Family: Menispermaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.688E-06 | 3.675E-02 | CA4, CA6 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.012E-05 | 1.102E-01 | CA4, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.519E-05 | 1.103E-01 | CA4, CA6 |
| BP | GO:0009987; cellular process | GO:0038194; thyroid-stimulating hormone signaling pathway | 3.106E-04 | 5.636E-01 | TSHR |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 2.749E-04 | 5.636E-01 | CA4, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 3.106E-04 | 5.636E-01 | TSHR |
| BP | GO:0009987; cellular process | GO:0019935; cyclic-nucleotide-mediated signaling | 1.545E-02 | 1.000E+00 | TSHR |
| BP | GO:0008152; metabolic process | GO:0030814; regulation of cAMP metabolic process | 1.791E-02 | 1.000E+00 | TSHR |
| CC | GO:0044425; membrane part | GO:0031226; intrinsic component of plasma membrane | 1.651E-02 | 1.000E+00 | CA4, TSHR |
| CC | GO:0016020; membrane | GO:0031253; cell projection membrane | 4.813E-02 | 1.000E+00 | CA4 |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | TSHR |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 5.160E-03 | 1.000E+00 | CA4, CA6 |
| MF | GO:0060089; molecular transducer activity | GO:0008528; G-protein coupled peptide receptor activity | 2.021E-02 | 1.000E+00 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.039E-06 | 1.427E-05 | CA4, CA6 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 3.446E-03 | 1.206E-02 | CA4 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 7.929E-03 | 1.466E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 8.377E-03 | 1.466E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.061E-02 | 1.486E-02 | TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 2.956E-02 | 3.448E-02 | TSHR |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 4.098E-02 | 4.098E-02 | TSHR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
