Plant Name: Magnolia liliflora
Taxonomic Information:
Plant ID: NPO30851
Plant Latin Name: Magnolia liliflora
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMGeographical Distribution:
China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CNR1; CNR2; PTAFR; | |
| TRPA1; | |
| MAPK1; | |
| PTGS1; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Small molecule receptor (family A GPCR) | CNR1 | Cannabinoid CB1 receptor | P21554 | CHEMBL218 |
| Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Small molecule receptor (family A GPCR) | PTAFR | Platelet activating factor receptor | P25105 | CHEMBL250 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0019233; sensory perception of pain | 6.299E-09 | 1.372E-04 | CNR1, CNR2, MAPK1, TRPA1 |
| MF | GO:0060089; molecular transducer activity | GO:0004949; cannabinoid receptor activity | 5.788E-07 | 6.302E-03 | CNR1, CNR2 |
| BP | GO:0009987; cellular process | GO:0038171; cannabinoid signaling pathway | 1.157E-06 | 8.400E-03 | CNR1, CNR2 |
| BP | GO:0008152; metabolic process | GO:0051001; negative regulation of nitric-oxide synthase activity | 4.048E-06 | 2.097E-02 | CNR1, CNR2 |
| BP | GO:0050896; response to stimulus | GO:0060359; response to ammonium ion | 7.525E-06 | 2.097E-02 | CNR1, MAPK1, PTAFR |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 8.846E-06 | 2.097E-02 | CNR1, CNR2, MAPK1, PTAFR, TRPA1 |
| BP | GO:0002376; immune system process | GO:0033004; negative regulation of mast cell activation | 1.059E-05 | 2.097E-02 | CNR1, CNR2 |
| BP | GO:0065007; biological regulation | GO:0045759; negative regulation of action potential | 1.271E-05 | 2.306E-02 | CNR1, CNR2 |
| CC | GO:0044464; cell part | GO:0030424; axon | 1.843E-04 | 1.338E-01 | CNR1, MAPK1, MAPT |
| CC | GO:0016020; membrane | GO:0016020; membrane | 2.769E-04 | 1.445E-01 | CNR1, CNR2, CYP3A4, LMNA, MAPK1, MAPT, PTAFR, PTGS1, TRPA1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 4.200E-04 | 1.492E-01 | MAPK1, MAPT |
| MF | Unclassified; | GO:0004871; signal transducer activity | 5.094E-04 | 1.608E-01 | CNR1, CNR2, MAPK1, PTAFR, TRPA1 |
| MF | GO:0003824; catalytic activity | GO:0004666; prostaglandin-endoperoxide synthase activity | 9.317E-04 | 2.184E-01 | PTGS1 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 1.231E-03 | 2.623E-01 | CNR2, MAPK1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.075E-04 | 2.158E-02 | CNR2, CNR1, PTAFR |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 8.883E-04 | 3.359E-02 | CNR1, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.091E-03 | 3.359E-02 | MAPK1, PTGS1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 1.292E-03 | 3.359E-02 | MAPK1, PTGS1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.696E-03 | 3.528E-02 | LMNA, MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.429E-03 | 4.211E-02 | MAPK1, MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 3.798E-03 | 5.643E-02 | CNR1, MAPK1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 4.455E-02 | 7.117E-02 | MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 3.325E-02 | 7.117E-02 | MAPK1 |
| 09150 Organismal Systems | 09159 Environmental adaptation | hsa04713 | Circadian entrainment | 4.195E-02 | 7.117E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PTAFR; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTAFR; |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PTAFR; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | PTAFR; |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | PTAFR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | PTAFR; MAPK1; |
| H00-H59: Diseases of the eye and adnexa | Ocular allergy | H00-H59 | PTAFR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Thrombocytopenia | D69.6, P61.0 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | PTAFR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | PTAFR; |
| H00-H59: Diseases of the eye and adnexa | Conjunctivitis | H10 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PTAFR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
