CMAUP Plant Collective Molecular Activities

Plant Name: Rhamnus frangula

Taxonomic Information:

Plant ID: NPO30631
Plant Latin Name: Rhamnus frangula
Taxonomy Genus: Frangula
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 106677
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; Albania; Lithuania; Finland; Bulgaria

Traditional Medicine System:

TCM

Geographical Distribution:

Lithuania; Albania; China; Finland; Bulgaria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; ALOX15; HSD17B10;
Protein Kinase	PIM1; CSNK2A1;
Lyase	CA12; CA1; CA9; CA13; CA7;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Transcription Factor	HIF1A;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.254E-13	1.797E-08	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.025E-10	7.440E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.941E-10	1.601E-06	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.650E-07	4.491E-04	BLM, CA1, CA12, CA13, CA7, CA9, ESR1, ESR2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	7.290E-07	1.588E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	4.370E-06	7.319E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	7.319E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.091E-05	1.584E-02	CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.787E-05	4.964E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	4.787E-05	4.964E-02	CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.428E-12	6.855E-11	CA12, CA1, CA7, CA9, CA13
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.839E-06	4.412E-05	CYP2C9, ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.248E-03	1.183E-02	CYP2C9, ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.678E-03	1.183E-02	ESR1, ESR2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.371E-03	1.183E-02	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.543E-03	1.183E-02	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.725E-03	1.183E-02	CYP2C9, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.143E-03	1.676E-02	ESR1, ESR2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.170E-03	1.302E-02	CYP2C9, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.001E-03	1.921E-02	CYP2C9, ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases