CMAUP Plant Collective Molecular Activities

Plant Name: Morinda umbellata

Taxonomic Information:

Plant ID: NPO30535
Plant Latin Name: Morinda umbellata
Taxonomy Genus: Morinda
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Miscellaneous ion channel	BCL2;
Enzyme_unclassified	ALOX15;
Unclassified	NPC1; MCL1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0010507; negative regulation of autophagy	4.734E-07	5.835E-03	BCL2, MCL1, NPC1
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	5.359E-07	5.835E-03	BCL2, MCL1
BP	GO:0009987; cellular process	GO:2000811; negative regulation of anoikis	6.423E-06	2.797E-02	BCL2, MCL1
BP	GO:0009987; cellular process	GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	2.997E-05	5.439E-02	BCL2, MCL1
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.177E-04	2.862E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	7.764E-04	3.315E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	7.764E-04	3.315E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	7.764E-04	3.315E-01	ALOX15
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	1.552E-03	4.225E-01	MCL1
CC	GO:0044464; cell part	GO:0005764; lysosome	1.949E-03	4.769E-01	NPC1, RAB9A
MF	GO:0005215; transporter activity	GO:0005215; transporter activity	2.611E-03	5.217E-01	BCL2, MCL1, NPC1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.798E-04	8.548E-03	BCL2, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	6.106E-04	8.548E-03	BCL2, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.802E-03	1.961E-02	BCL2, MCL1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.134E-03	1.961E-02	BCL2, MCL1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	4.049E-02	ALOX15
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.549E-02	4.477E-02	BCL2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.769E-02	4.477E-02	ALOX15
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.916E-02	4.477E-02	BCL2
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.965E-02	4.477E-02	BCL2
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.965E-02	4.477E-02	BCL2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases