CMAUP Plant Collective Molecular Activities

Plant Name: Cimicifuga dahurica

Taxonomic Information:

Plant ID: NPO30530
Plant Latin Name: Cimicifuga dahurica
Taxonomy Genus: Actaea
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antibacterial; Antiviral; Depurative; Diaphoretic; Diuretic; Febrifuge; Sedative; Tonic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Enzyme_unclassified	TDP1; HSD17B10;
Protein Kinase	MAPK1;
Lyase	CA2; CA14; CA7; CA6; CA12; CA1; CA9; CA5B; CA3; CA5A;
Metallo protease	MMP2; MMP9; MMP1;
Transcription Factor	NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.987E-14	1.902E-10	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PTPN1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.784E-28	6.063E-24	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	3.911E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.269E-22	2.471E-18	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.515E-20	8.245E-17	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.524E-05	1.508E-02	CA1, CA2
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	3.980E-05	3.611E-02	MMP1, MMP2, MMP9
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	4.561E-05	3.972E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.272E-27	1.590E-25	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	7.190E-08	4.493E-06	MMP1, MMP2, MAPK1, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.643E-05	1.518E-03	MMP1, MMP2, MAPK1, MMP9, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.339E-04	3.347E-03	MMP2, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.262E-04	3.347E-03	MMP2, MAPK1, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.724E-04	3.591E-03	MAPK1, MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.507E-04	6.197E-03	LMNA, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	3.966E-04	6.197E-03	MAPK1, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.034E-03	1.436E-02	MMP2, MAPK1, MMP9
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	1.903E-03	1.577E-02	MAPK1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases