Plant Name: Rhinacanthus nasutus
Taxonomic Information:
Plant ID: NPO3049
Plant Latin Name: Rhinacanthus nasutus
Taxonomy Genus: Rhinacanthus
Taxonomy Family: Acanthaceae
Plant External Links:
NCBI TaxonomyDB:
537489
Plant-of-the-World-Online:
53554-1
Used in Medicines:
Country/Region:
Philippines; Indonesia; India; Vietnam; China; Laos; ThailandTraditional Medicine System:
TCMGeographical Distribution:
Madagascar; Angola; Bangladesh; Myanmar; Philippines; Indonesia; India; Cambodia; Mauritius; Vietnam; China; Laos; Sri Lanka; Thailand; Comoros
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.976E-10 | 7.870E-07 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.235E-07 | 9.267E-04 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.860E-29 | 1.058E-24 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 3.614E-06 | 4.142E-03 | CA1, CA2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.874E-24 | 7.484E-20 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.830E-21 | 1.232E-17 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.083E-05 | 1.072E-02 | CA2, CA7 |
| BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 1.876E-05 | 1.776E-02 | CA2, CA7 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.725E-28 | 1.208E-27 | CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 1.342E-02 | 3.132E-02 | CA2 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04964 | Proximal tubule bicarbonate reclamation | 1.144E-02 | 3.132E-02 | CA2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 3.640E-02 | 5.096E-02 | CA2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.495E-02 | 5.096E-02 | CA2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04972 | Pancreatic secretion | 4.699E-02 | 5.482E-02 | CA2 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 9.244E-02 | 9.244E-02 | HTT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
