CMAUP Plant Collective Molecular Activities

Plant Name: Combretum quadrangulare

Taxonomic Information:

Plant ID: NPO30384
Plant Latin Name: Combretum quadrangulare
Taxonomy Genus: Combretum
Taxonomy Family: Combretaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Vietnam

Traditional Medicine System:

Geographical Distribution:

Vietnam

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; HSD17B10; AKR1B10;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Aspartic protease	BACE1;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0010894; negative regulation of steroid biosynthetic process	2.838E-05	2.676E-01	NFKB1, NR1H4
BP	GO:0008152; metabolic process	GO:0033619; membrane protein proteolysis	7.452E-05	2.676E-01	BACE1, NFKB1
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	9.785E-05	2.676E-01	ALPL, NFKB1, NR1H4
MF	GO:0005488; binding	GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding	2.843E-04	2.676E-01	NFKB1, NR1H4
MF	GO:0140110; transcription regulator activity	GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	5.370E-04	3.220E-01	NFKB1, NR1H4
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	2.534E-03	5.110E-01	NFKB1
CC	GO:0044464; cell part	GO:0005764; lysosome	4.017E-03	6.117E-01	AKR1B10, GAA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.546E-05	2.864E-03	AKR1B10, GAA
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.409E-04	1.389E-02	AKR1B10, GAA, ALPL, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.433E-03	3.009E-02	BACE1, HSD17B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.115E-02	6.118E-02	AKR1B10
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.978E-02	6.118E-02	NFKB1
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	1.703E-02	6.118E-02	NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.909E-02	6.118E-02	NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	3.210E-02	6.118E-02	NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	3.652E-02	6.118E-02	NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	3.584E-02	6.118E-02	NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases