Plant Name: Calotropis gigantea
Taxonomic Information:
Plant ID: NPO30295
Plant Latin Name: Calotropis gigantea
Taxonomy Genus: Calotropis
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
95173-1
Used in Medicines:
Unknown.
Geographical Distribution:
Bangladesh; Nepal; Cambodia; Laos; Venezuela; Australia; Cuba; China; Thailand; Tanzania; Maldives; Philippines; Indonesia; United States; Trinidad and Tobago; Vietnam; Angola; Myanmar; India; Mozambique; Colombia; Sri Lanka; Kenya; Fiji
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | ATP12A | Potassium-transporting ATPase alpha chain 2 | P54707 | CHEMBL2933 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038194; thyroid-stimulating hormone signaling pathway | 4.141E-04 | 6.012E-01 | PAX8 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 6.012E-01 | PAX8 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 6.935E-01 | NPC1, RAB9A |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | NPC1 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.797E-02 | 1.000E+00 | ATP12A |
| MF | Unclassified; | GO:0004871; signal transducer activity | 4.187E-02 | 1.000E+00 | NPC1, PAX8 |
| MF | GO:0005488; binding | GO:0032555; purine ribonucleotide binding | 4.854E-02 | 1.000E+00 | ATP12A, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 5.788E-03 | 3.770E-02 | PAX8 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.413E-02 | 3.770E-02 | PAX8 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.438E-02 | 3.770E-02 | NPC1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00190 | Oxidative phosphorylation | 2.634E-02 | 3.770E-02 | ATP12A |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.693E-02 | 3.770E-02 | RAB9A |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 3.552E-02 | 4.144E-02 | PAX8 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 7.707E-02 | 7.707E-02 | PAX8 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
