CMAUP Plant Collective Molecular Activities

Plant Name: Artemisia caucasica

Taxonomic Information:

Plant ID: NPO3017
Plant Latin Name: Artemisia caucasica
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 1227620
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	AXL; PIM1; KDR; IGF1R; FLT3; AURKB; MET; CDK1;
Lyase	CA1; CA9;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX12; HSD17B10; NOX4; POLB;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	4.277E-07	7.293E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	6.072E-07	8.263E-04	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	7.867E-07	8.790E-04	AURKB, FLT3, IGF1R, KDR, PIM1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.361E-23	2.354E-21	CA12, CA1, CA3, CA2, CA5A, CA4, CA7, CA6, CA9, CA14, CA13
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.516E-11	1.311E-09	CAMK2B, SRC, MMP2, KDR, AKT1, PIK3R1, TP53, HIF1A, MMP9, MET, PTK2, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.010E-09	1.736E-07	GSK3B, FLT3, DAPK1, MMP2, PIK3R1, HIF1A, MMP9, NFKB1, PTK2, IGF1R, AKT1, MET, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.427E-08	1.186E-06	ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.690E-08	1.164E-06	FLT3, MMP3, TP53, MPO, MMP9, MET, NFKB1, PTK2, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	6.407E-07	1.108E-05	GSK3B, KDR, AKT1, PIK3R1, PKN1, TP53, MET, PTK2, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.045E-07	4.422E-06	FLT3, AKT1, PIK3R1, TP53, MET, HIF1A
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.522E-08	2.106E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.667E-08	2.106E-06	CYP2C8, PLA2G1B, CYP1A2, ALOX15, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	8.515E-07	1.314E-05	GSK3B, CSNK2A1, AKT1, RAB9A, PIK3R1, TP53, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	9.872E-07	1.314E-05	GSK3B, SRC, KDR, AKT1, PIK3R1, MET, PTK2, IGF1R
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.669E-07	8.975E-06	DAPK1, SRC, MMP2, MMP9, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.115E-06	1.378E-05	GSK3B, AKT1, PIK3R1, TP53, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	9.745E-07	1.314E-05	CAMK2B, GSK3B, SRC, AKT1, PIK3R1, PTK2
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.372E-06	1.583E-05	SRC, AKT1, STAT6, PIK3R1, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.488E-06	2.677E-05	FLT3, PIM1, AKT1, PIK3R1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.630E-06	2.677E-05	CAMK2B, AKT1, PIK3R1, HIF1A, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	3.858E-06	3.337E-05	CASP7, MMP3, AKT1, PIK3R1, MMP9, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	3.494E-06	3.337E-05	SRC, KDR, AKT1, PIK3R1, PTK2
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	4.794E-06	3.770E-05	CAMK2B, AKT1, PIK3R1, TP53, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.789E-06	3.337E-05	CYP2C8, PLA2G1B, ALOX5, ALOX15, ALOX12
09150 Organismal Systems	09151 Immune system	hsa04062	Chemokine signaling pathway	7.082E-06	4.901E-05	GSK3B, CXCR1, SRC, AKT1, PIK3R1, NFKB1, PTK2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	5.795E-06	4.359E-05	GSK3B, SRC, AKT1, PIK3R1, TP53, HIF1A
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	6.385E-06	4.603E-05	CAMK2B, GSK3B, AKT1, PIK3R1, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.352E-05	8.064E-05	PLA2G1B, MAOA, ALOX15, AKR1B1, ALOX12, PYGL, CYP3A4, CYP19A1, HSD17B10, CYP2C8, ALOX5, HSD17B2, CYP1A2, ALDH1A1, CYP1A1, XDH
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.172E-05	7.239E-05	GSK3B, CSNK2A1, CDK1, AKT1, PIK3R1, TP53, NFKB1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.794E-06	3.770E-05	CYP2C8, CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	7.424E-06	4.940E-05	AKT1, PIK3R1, TP53, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	7.954E-06	5.096E-05	GSK3B, SRC, AKT1, PIK3R1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.488E-05	1.304E-04	PLA2G1B, KDR, AKT1, PIK3R1, MET, NFKB1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4.133E-05	1.986E-04	MMP2, PIM1, AKT1, PIK3R1, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	2.924E-05	1.488E-04	AKT1, PIK3R1, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.900E-05	1.027E-04	AKT1, PIK3R1, TP53, NFKB1, PTK2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.754E-05	1.856E-04	SRC, MMP2, AKT1, PIK3R1, MMP9
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.506E-05	8.685E-05	CYP2C8, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.954E-05	2.700E-04	GSK3B, AKT1, PIK3R1, PYGL, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	6.777E-05	2.931E-04	CYP2C8, MAOA, ALOX5, ALOX15, ALOX12
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.298E-04	4.868E-04	POLB, SRC, CDK1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.351E-04	4.871E-04	ABCC1, PIM1, CYP1B1, TP53, MMP9, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	9.403E-05	3.873E-04	ABCC1, AKT1, PIK3R1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.519E-04	5.035E-04	SRC, KDR, AKT1, PIK3R1, MET, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.322E-04	4.868E-04	CAMK2B, GSK3B, MAOA, AKT1, DRD4
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	6.087E-05	2.700E-04	ALK, AKT1, PIK3R1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.526E-04	5.035E-04	GSK3B, AKT1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	4.539E-05	2.122E-04	GSK3B, AKT1, PIK3R1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.940E-04	5.785E-04	CASP7, AKT1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	9.088E-05	3.835E-04	GSK3B, AKT1, PIK3R1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.161E-04	4.564E-04	AKT1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.161E-04	4.564E-04	AKT1, PIK3R1, MET, HIF1A
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	2.755E-04	7.945E-04	GSK3B, CASP7, AKT1, PIK3R1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	4.468E-04	1.267E-03	POLB, GSK3B, AKT1, PIK3R1, TP53, NFKB1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.586E-05	8.851E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.304E-04	4.868E-04	CXCR1, SRC, MET, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	5.418E-04	1.465E-03	GSK3B, CASP1, AKT1, PIK3R1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.718E-04	5.308E-04	AKT1, PIK3R1, TP53, NFKB1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5.308E-04	1.458E-03	CAMK2B, SRC, ALOX12, PIK3R1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5.308E-04	1.458E-03	CDK1, AKT1, PIK3R1, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.380E-04	4.873E-04	CYP2C8, MAOA, CYP1A2, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.718E-04	5.308E-04	GSK3B, AKT1, PIK3R1, NFKB1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	3.064E-03	7.043E-03	CXCR1, SRC, KDR, MET, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.065E-03	2.750E-03	ALOX5, AKT1, PIK3R1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	6.641E-04	1.768E-03	GSK3B, AKT1, PIK3R1, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2.104E-03	4.985E-03	GSK3B, AKT1, PIK3R1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.946E-03	4.742E-03	GSK3B, AKT1, PIK3R1, PYGL
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	2.104E-03	4.985E-03	CAMK2B, GSK3B, CSNK2A1, TP53
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	1.065E-03	2.750E-03	MMP2, PIK3R1, MMP9, PTK2
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	3.094E-03	7.043E-03	PIM1, AKT1, STAT6, PIK3R1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.543E-04	5.035E-04	CA2, NR1H4, CYP3A4, ABCG2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.718E-04	5.308E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.811E-04	5.497E-04	CSNK2A1, SRC, MET, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05100	Bacterial invasion of epithelial cells	2.219E-04	6.508E-04	SRC, PIK3R1, MET, PTK2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	3.853E-03	8.546E-03	BACE1, GSK3B, CASP7, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	4.304E-03	9.426E-03	CASP1, PKN1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.926E-03	6.840E-03	CASP7, CASP1, NFKB1
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	1.860E-03	4.597E-03	AKT1, PIK3R1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.544E-03	3.872E-03	AKT1, PIK3R1, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.200E-03	3.054E-03	CASP7, CASP1, NFKB1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.424E-03	7.692E-03	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.415E-04	4.894E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; CA1; CA9;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CA9;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
NA: NA	GIST	NA	FLT3;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases