Plant Name: Alvaradoa haitiensis
Taxonomic Information:
Plant ID: NPO30060
Plant Latin Name: Alvaradoa haitiensis
Taxonomy Genus: Alvaradoa
Taxonomy Family: Picramniaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 4.817E-05 | 3.496E-01 | MAPK1, MAPT |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 3.548E-05 | 3.496E-01 | MAPK1, MAPT |
| BP | GO:0008152; metabolic process | GO:0019858; cytosine metabolic process | 3.106E-04 | 6.614E-01 | MAPK1 |
| BP | GO:0007610; behavior | GO:0007611; learning or memory | 4.386E-04 | 6.614E-01 | MAPK1, MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 1.397E-03 | 6.614E-01 | MAPT |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.397E-03 | 6.614E-01 | RECQL |
| CC | GO:0044464; cell part | GO:0030424; axon | 5.244E-04 | 6.614E-01 | MAPK1, MAPT |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 2.137E-04 | 6.614E-01 | MAPK1, MAPT |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 7.764E-04 | 6.614E-01 | RECQL |
| MF | GO:0003824; catalytic activity | GO:0043140; ATP-dependent 3'-5' DNA helicase activity | 1.087E-03 | 6.614E-01 | RECQL |
| MF | GO:0005488; binding | GO:0036310; annealing helicase activity | 1.242E-03 | 6.614E-01 | RECQL |
| CC | Unclassified; | GO:0031143; pseudopodium | 2.638E-03 | 7.328E-01 | MAPK1 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 7.328E-01 | MAPT |
| MF | GO:0003824; catalytic activity | GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity | 2.483E-03 | 7.328E-01 | MAPK1 |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 2.483E-03 | 7.328E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.093E-04 | 1.800E-02 | MAPK1, MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 4.817E-04 | 2.071E-02 | MAPK1, MAPT |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 4.344E-03 | 2.673E-02 | MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05020 | Prion diseases | 5.241E-03 | 2.673E-02 | MAPK1 |
| 09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 5.839E-03 | 2.673E-02 | MAPK1 |
| Unclassified | Unclassified | hsa04320 | Dorso-ventral axis formation | 4.045E-03 | 2.673E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 8.526E-03 | 2.673E-02 | MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 8.973E-03 | 2.673E-02 | MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 9.123E-03 | 2.673E-02 | MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 9.272E-03 | 2.673E-02 | MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
