CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL;
Protein Kinase	MAPK1;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 3 of 3 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	4.817E-05	3.496E-01	MAPK1, MAPT
BP	GO:0008152; metabolic process	GO:0019858; cytosine metabolic process	3.106E-04	6.614E-01	MAPK1
BP	GO:0007610; behavior	GO:0007611; learning or memory	4.386E-04	6.614E-01	MAPK1, MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	1.397E-03	6.614E-01	MAPT
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	1.397E-03	6.614E-01	RECQL
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.548E-05	3.496E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	5.244E-04	6.614E-01	MAPK1, MAPT
CC	Unclassified;	GO:0031143; pseudopodium	2.638E-03	7.328E-01	MAPK1
MF	GO:0005488; binding	GO:0019902; phosphatase binding	2.137E-04	6.614E-01	MAPK1, MAPT
MF	GO:0003824; catalytic activity	GO:0009378; four-way junction helicase activity	7.764E-04	6.614E-01	RECQL

Showing 1 to 10 of 15 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	4.817E-04	2.071E-02	MAPK1, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	9.123E-03	2.673E-02	MAPK1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5.839E-03	2.673E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	8.973E-03	2.673E-02	MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.093E-04	1.800E-02	MAPK1, MAPT
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	4.344E-03	2.673E-02	MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05020	Prion diseases	5.241E-03	2.673E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	8.526E-03	2.673E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	9.272E-03	2.673E-02	MAPK1
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	4.045E-03	2.673E-02	MAPK1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Alvaradoa haitiensis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities