CMAUP Plant Collective Molecular Activities

Plant Name: Citrus grandis

Taxonomic Information:

Plant ID: NPO30045
Plant Latin Name: Citrus grandis
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Phosphodiesterase 4	PDE4D;
Lyase	CA12; CA9;
Enzyme_unclassified	UBE2N;
ATP-binding cassette	ABCB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.428E-06	1.835E-01	CA12, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.042E-05	5.489E-01	CA12, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.563E-05	5.489E-01	CA12, CA9
BP	GO:0032501; multicellular organismal process	GO:1901898; negative regulation of relaxation of cardiac muscle	6.212E-04	8.820E-01	PDE4D
BP	GO:0009987; cellular process	GO:0050852; T cell receptor signaling pathway	8.230E-04	8.820E-01	PDE4D, UBE2N
MF	GO:0005488; binding	GO:0008144; drug binding	8.278E-04	8.820E-01	ABCB1, CYP19A1, PDE4D, UBE2N
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	8.349E-04	8.820E-01	ABCB1, CA12, CA9, CYP19A1, PDE4D, UBE2N

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.018E-05	1.120E-04	CA12, CA9
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.491E-02	4.645E-02	CYP19A1
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.313E-02	4.645E-02	ABCB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.728E-02	4.645E-02	CYP19A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.111E-02	4.645E-02	ABCB1
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	2.699E-02	4.949E-02	PDE4D
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.824E-02	7.118E-02	PDE4D
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4.041E-02	6.350E-02	UBE2N
09100 Metabolism	09104 Nucleotide metabolism	hsa00230	Purine metabolism	5.166E-02	7.103E-02	PDE4D
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	8.587E-02	9.445E-02	ABCB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases