CMAUP Plant Collective Molecular Activities

Plant Name: Caesalpinia sappan

Taxonomic Information:

Plant ID: NPO29935
Plant Latin Name: Caesalpinia sappan
Taxonomy Genus: Caesalpinia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; HPGD; ALOX15; NOX4; ALDH1A1;
Protein Kinase	MET; ERBB2; EGFR; FGFR1; FLT1; KIT; KDR; SRC;
Lyase	CA2; CA1; CA12; CA9; CA14; CA5B; CA5A; CA3; CA7; CA4; CA6;
Lysine demethylase	KDM4E;
Serine protease	PLG;
Transferase	FUT7;
Unclassified	LMNA; MAPT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	ERBB2	Receptor protein-tyrosine kinase erbB-2	P04626	CHEMBL1824
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	FGFR1	Fibroblast growth factor receptor 1	P11362	CHEMBL3650
Protein Kinase	FLT1	Vascular endothelial growth factor receptor 1	P17948	CHEMBL1868
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	SRC	Tyrosine-protein kinase SRC	P12931	CHEMBL267
Serine protease	PLG	Plasminogen	P00747	CHEMBL1801
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	5.923E-10	8.061E-07	EGFR, ERBB2, KDR, KIT
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	2.845E-09	3.292E-06	EGFR, ERBB2, FGFR1, KIT, MET, NOX4, SRC
MF	GO:0003824; catalytic activity	GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity	5.324E-08	5.270E-05	EGFR, ERBB2, FGFR1, KIT, MET
BP	GO:0065007; biological regulation	GO:0043406; positive regulation of MAP kinase activity	1.280E-07	9.958E-05	EGFR, ERBB2, FGFR1, FLT1, KIT, NOX4, SRC
BP	GO:0065007; biological regulation	GO:0010863; positive regulation of phospholipase C activity	1.874E-07	1.317E-04	EGFR, FGFR1, FLT1, KIT
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.304E-07	1.568E-04	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.603E-07	2.021E-04	CA2, CA4, CA9, EGFR, ERBB2, HPGD
BP	GO:0008152; metabolic process	GO:0046854; phosphatidylinositol phosphorylation	4.112E-07	2.035E-04	EGFR, ERBB2, FGFR1, KIT, MET
BP	GO:0009987; cellular process	GO:2001028; positive regulation of endothelial cell chemotaxis	9.568E-07	3.472E-04	FGFR1, KDR, MET
MF	GO:0005488; binding	GO:0019838; growth factor binding	1.591E-06	5.500E-04	EGFR, ERBB2, FGFR1, FLT1, KDR
BP	GO:0009987; cellular process	GO:0071363; cellular response to growth factor stimulus	1.802E-06	6.036E-04	EGFR, ERBB2, FLT1, KDR, NOX4, SRC
BP	GO:0009987; cellular process	GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling	3.186E-06	9.911E-04	FGFR1, FLT1, KDR, KIT
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.130E-29	4.637E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0032502; developmental process	GO:0002009; morphogenesis of an epithelium	4.060E-06	1.211E-03	CA2, CA9, EGFR, FGFR1, MET, SRC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	2.002E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	1.215E-05	2.896E-03	ALOX15, EGFR, KDR, NOX4, SRC
BP	GO:0008152; metabolic process	GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity	1.334E-05	3.091E-03	FLT1, KIT, SRC
BP	GO:0009987; cellular process	GO:0038128; ERBB2 signaling pathway	2.975E-05	5.943E-03	EGFR, ERBB2, SRC
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	3.208E-05	6.292E-03	EGFR, ERBB2, MAPT, MET
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.484E-05	6.355E-03	ALOX15, HPGD
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.484E-05	6.355E-03	CA1, CA2
MF	GO:0005488; binding	GO:0000166; nucleotide binding	3.525E-05	6.355E-03	ALDH1A1, EGFR, ERBB2, FGFR1, FLT1, HPGD, KDR, KIT, MET, NOX4, SRC, XDH
MF	GO:0098772; molecular function regulator	GO:0005088; Ras guanyl-nucleotide exchange factor activity	3.744E-05	6.471E-03	EGFR, ERBB2, FGFR1, KIT, MET
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	4.873E-05	7.861E-03	FLT1, KDR
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	5.235E-05	8.260E-03	EGFR, KDR, SRC
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	6.607E-05	9.991E-03	ALOX15, CA2, EGFR, KDR, KIT, SRC
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.166E-22	1.269E-18	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.749E-21	2.041E-17	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.314E-28	1.065E-26	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.182E-08	8.836E-07	FLT1, SRC, KIT, KDR, MET, EGFR, FGFR1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.840E-08	1.307E-06	ERBB2, KIT, MET, EGFR, FGFR1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	8.015E-08	1.623E-06	SRC, ERBB2, MET, EGFR, FGFR1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.922E-07	6.644E-06	SRC, ERBB2, KDR, MET, EGFR, FGFR1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	4.781E-07	6.644E-06	FLT1, SRC, ERBB2, KDR, MET, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	9.461E-07	1.095E-05	FLT1, KIT, KDR, MET, EGFR, FGFR1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	2.036E-06	2.062E-05	FLT1, SRC, KIT, KDR, MET, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	9.880E-06	8.892E-05	FLT1, KIT, KDR, MET, EGFR, FGFR1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4.273E-05	3.147E-04	FLT1, KIT, KDR, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.124E-05	2.530E-04	SRC, ERBB2, EGFR
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.844E-04	1.601E-03	KIT, ERBB2, MET, EGFR, FGFR1
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.429E-04	9.646E-04	SRC, MET, EGFR
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.625E-04	1.012E-03	MET, EGFR, FGFR1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.170E-04	1.605E-03	ERBB2, EGFR, FGFR1
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	2.965E-04	1.601E-03	SRC, ERBB2, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.868E-04	2.319E-03	FLT1, ERBB2, EGFR
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5.396E-04	2.428E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	SRC;
I00-I99: Diseases of the circulatory system	Severe coronary heart disease	I25.1	FGFR1;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lymphoma	C81-C86	FGFR1; ERBB2;
H00-H59: Diseases of the eye and adnexa	Retinal venous occlusion	H34.8	ERBB2;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
J00-J99: Diseases of the respiratory system	Asthma	J45	ERBB2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; FGFR1; ERBB2; SRC;
C00-D49: Neoplasms	Cancer	C00-C96	MET; FGFR1; ERBB2; SRC;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	SRC;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	ERBB2;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	ERBB2; SRC;
C00-D49: Neoplasms	Prostate cancer	C61	ERBB2;
C00-D49: Neoplasms	HER2-positive urogenital cancer	NA	ERBB2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	ERBB2;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ERBB2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	SRC;
C00-D49: Neoplasms	Osteosarcoma	C40-C41	SRC;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	FGFR1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Bladder cancer	C67	ERBB2;
C00-D49: Neoplasms	Breast cancer	C50	ERBB2;
C00-D49: Neoplasms	Brain cancer	C71, D33	SRC;
C00-D49: Neoplasms	Advanced breast cancer	C50	SRC;
C00-D49: Neoplasms	Endometrial cancer	C54.1	FGFR1;
C00-D49: Neoplasms	Multiple myeloma	C90	SRC;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET;
I00-I99: Diseases of the circulatory system	Peripheral arterial occlusive disease	I73.9	FGFR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	ERBB2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	ERBB2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	SRC;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases