CMAUP Plant Collective Molecular Activities

Plant Name: Aconitum carmichaeli

Taxonomic Information:

Plant ID: NPO29861
Plant Latin Name: Aconitum carmichaeli
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 707241-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Vietnam; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR2B; HTR2A; DRD3; HTR2C; DRD2; DRD4;
Peptide receptor (family A GPCR)	TSHR;
Lyase	CA2; CA3; CA1; CA7; CA12; CA14; CA9;
Enzyme_unclassified	HSD17B10;
Transcription Factor	HIF1A;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR2A	Serotonin 2a (5-HT2a) receptor	P28223	CHEMBL224
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.296E-13	1.248E-09	CA1, CA12, CA2, CA3, CA7, CA9
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.694E-10	4.512E-07	CA2, CA7, DRD2, DRD3, HTR2A, HTR2B, HTR2C
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.972E-09	2.147E-06	DRD2, DRD3, DRD4, HTR2A
BP	GO:0008152; metabolic process	GO:0010513; positive regulation of phosphatidylinositol biosynthetic process	5.656E-09	5.355E-06	HTR2A, HTR2B, HTR2C
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	3.162E-08	2.374E-05	DRD2, DRD3, DRD4
BP	GO:0051179; localization	GO:0051209; release of sequestered calcium ion into cytosol	5.982E-08	3.520E-05	DRD2, HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	6.769E-08	3.779E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	9.302E-08	4.560E-05	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	9.302E-08	4.560E-05	DRD2, DRD3, HTR2B
MF	GO:0005488; binding	GO:0051378; serotonin binding	9.302E-08	4.560E-05	HTR2A, HTR2B, HTR2C
MF	GO:0005488; binding	GO:0035240; dopamine binding	1.611E-07	6.744E-05	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007208; phospholipase C-activating serotonin receptor signaling pathway	7.290E-07	2.301E-04	HTR2A, HTR2C
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	7.290E-07	2.301E-04	HTR2A, HTR2C
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	9.919E-07	2.833E-04	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.133E-06	3.046E-04	HTR2A, HTR2B, HTR2C
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	1.133E-06	3.046E-04	HTR2A, HTR2B, HTR2C
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	1.454E-06	3.724E-04	DRD2, DRD3, DRD4
BP	GO:0008152; metabolic process	GO:0042417; dopamine metabolic process	1.830E-06	4.477E-04	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	1.830E-06	4.477E-04	DRD2, DRD3, HTR2A
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	2.186E-06	5.011E-04	DRD2, DRD3
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.186E-06	5.011E-04	CA2, CA7
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	2.186E-06	5.011E-04	DRD2, DRD4
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	2.764E-06	6.024E-04	DRD2, DRD3, DRD4
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	7.279E-06	1.277E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0008542; visual learning	9.556E-06	1.553E-03	DRD2, DRD3, HIF1A
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	1.091E-05	1.710E-03	DRD3, DRD4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	1.710E-03	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.249E-05	1.929E-03	CA2, DRD2, DRD3, HIF1A, HTR2A, HTR2B, LMNA
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	1.545E-05	2.304E-03	DRD2, DRD3, DRD4, HTR2C
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	2.251E-05	3.268E-03	DRD2, HTR2A, HTR2B, HTR2C
BP	GO:0009987; cellular process	GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway	3.252E-05	4.392E-03	DRD2, DRD3, TSHR
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.267E-05	4.392E-03	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.532E-05	5.805E-03	CA1, CA12, CA2, CA3, CA7, CA9
BP	GO:0051179; localization	GO:0002028; regulation of sodium ion transport	4.981E-05	6.198E-03	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	5.654E-05	6.728E-03	DRD2, DRD3
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	5.654E-05	6.728E-03	CA2, CA7
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	5.654E-05	6.728E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0048149; behavioral response to ethanol	6.593E-05	7.596E-03	DRD2, DRD4
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	6.593E-05	7.596E-03	DRD2, HTR2A
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.271E-19	1.365E-14	CA1, CA12, CA14, CA2, CA3, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.686E-15	4.013E-11	CA1, CA12, CA14, CA2, CA3, CA7, CA9
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.097E-04	1.142E-02	DRD2, DRD3, DRD4, HTR2A, HTR2B, HTR2C, TSHR
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.409E-04	3.952E-02	CA2, CA9, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.484E-18	5.195E-17	CA12, CA1, CA3, CA2, CA7, CA9, CA14
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.566E-09	2.740E-08	HTR2B, HTR2C, HTR2A, DRD2, DRD3, DRD4, TSHR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	7.971E-07	9.299E-06	HTR2B, HTR2C, HTR2A, DRD2
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7.380E-05	6.458E-04	HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.098E-04	7.685E-04	HTR2B, HTR2C, HTR2A
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.669E-04	9.733E-04	DRD2, DRD3, DRD4
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	4.443E-04	2.221E-03	HTR2B, HTR2C, HTR2A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.214E-02	5.313E-02	DRD2, TSHR
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.271E-02	7.949E-02	CA2
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.938E-02	7.536E-02	CA2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2A; HTR2C;
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep maintenance insomnia	F51.0, G47.0	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3; HTR2A; HTR2C;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HTR2A;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR2C;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HTR2A;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2A; HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3; HTR2C;
NA: NA	Addiction	NA	HTR2A;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR2A; HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2A; HTR2B; HTR2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HTR2A; HTR2C;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Erythropoietic porphyria	E80.0	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR2C;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3; HTR2C;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2A; HTR2B;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C;
I00-I99: Diseases of the circulatory system	Hemorrhoids	I84	HTR2A;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	HTR2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C;
NA: NA	Primary insomnia	NA	HTR2C;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases