| ICD10 Disease Category |
Disease Name |
ICD10 Code |
Associated Disease Targets
(Association Ref: TTD database) |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Gout |
M10 |
AKR1B1; |
| C00-D49: Neoplasms |
Glioma |
C71 |
KDR; |
| C00-D49: Neoplasms |
Gliosarcoma |
NA |
FLT3; |
| NA: NA |
GIST |
NA |
FLT3; |
| C00-D49: Neoplasms |
Malignant adrenal gland cancer |
C74.0 |
IGF1R; |
| I00-I99: Diseases of the circulatory system |
Cardiovascular disorder |
I00-I99 |
KDR; |
| C00-D49: Neoplasms |
Glioblastoma |
NA |
FLT3; |
| H00-H59: Diseases of the eye and adnexa |
Glaucoma |
H40-H42 |
ACHE; AKR1B1; |
| C00-D49: Neoplasms |
Gastrointestinal cancers |
C15-C26 |
KDR; |
| C00-D49: Neoplasms |
Renal cancer |
C64 |
KDR; |
| NA: NA |
Upper abdominal bloating |
NA |
ACHE; |
| C00-D49: Neoplasms |
Head and neck cancer |
C07-C14, C32-C33 |
KDR; AKR1B1; |
| I00-I99: Diseases of the circulatory system |
Heart disease |
I00-I52 |
MET; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified |
Growth failure |
R62.8 |
IGF1R; |
| H00-H59: Diseases of the eye and adnexa |
Graves' ophthalmopathy |
H06.2 |
IGF1R; |
| NA: NA |
Anaplastic mixed oligoastrocytoma |
NA |
FLT3; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hormone deficiency |
E00-E90 |
IGF1R; |
| C00-D49: Neoplasms |
Solid tumours |
C00-D48 |
MET; AURKB; IGF1R; KDR; FLT3; MMP9; MMP2; |
| C00-D49: Neoplasms |
Advanced malignancies |
C00-C96 |
KDR; |
| C00-D49: Neoplasms |
Fallopian tube cancer |
C57.0, D28.2 |
KDR; |
| I00-I99: Diseases of the circulatory system |
Angiogenesis disorder |
I00-I99 |
KDR; |
| C00-D49: Neoplasms |
Hepatocellular carcinoma |
C22.0 |
MET; IGF1R; KDR; |
| NA: NA |
Hematopoietic stem cell transplantation |
NA |
FLT3; |
| A00-B99: Certain infectious and parasitic diseases |
Helminth infection |
A00-B99 |
ACHE; |
| C00-D49: Neoplasms |
Hematological malignancies |
C81-C86 |
AURKB; |
| S00-T88: Injury, poisoning and certain other consequences of external causes |
Poison intoxication |
T36-T50 |
ACHE; |
| C00-D49: Neoplasms |
Peritoneal cavity cancer |
NA |
KDR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes |
Poisoning due to pesticides and chemicals |
T36-T50 |
ACHE; |
| C00-D49: Neoplasms |
Gastric cancer |
C16 |
KDR; |
| J00-J99: Diseases of the respiratory system |
Airway inflammation |
J00-J99 |
FLT3; |
| C00-D49: Neoplasms |
Advanced solid tumor |
C00-C75, C7A, C7B |
MET; |
| C00-D49: Neoplasms |
Melanoma |
C43 |
KDR; |
| C00-D49: Neoplasms |
Medullary thyroid cancer |
C73 |
KDR; |
| G00-G99: Diseases of the nervous system G00-G99 |
Epileptic seizures |
G40, P90, R56 |
ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 |
Alzheimer disease |
G30 |
ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Anxiety disorder |
F32, F40-F42 |
ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 |
Motor neurone disease |
G12.2 |
IGF1R; |
| C00-D49: Neoplasms |
Multiple myeloma |
C90 |
IGF1R; |
| C00-D49: Neoplasms |
Colorectal cancer |
C18-C21 |
IGF1R; KDR; FLT3; MMP9; |
| C00-D49: Neoplasms |
Colon cancer |
C50 |
FLT3; |
| C00-D49: Neoplasms |
Renal cell carcinoma |
NA |
KDR; MMP2; |
| NA: NA |
Early satiation associated with functional dyspepsia |
NA |
ACHE; |
| C00-D49: Neoplasms |
Metastatic breast cancer |
C50 |
KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Mild cognitive impairment |
F06.7 |
ACHE; |
| C00-D49: Neoplasms |
Advanced renal cell carcinoma |
C64 |
KDR; |
| I00-I99: Diseases of the circulatory system |
Stroke |
I61-I63, I80-I82 |
MMP9; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Rheumatoid arthritis |
M05-M06 |
AKR1B1; MMP1; |
| C00-D49: Neoplasms |
AML |
NA |
KDR; FLT3; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetic cataract |
E10.36, E11.36 |
AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetic complication |
E08-E13 |
AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetic neuropathy |
E11.40 |
AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetic nephropathy |
E11.21 |
MMP1; |
| C00-D49: Neoplasms |
Acute myeloid leukemia |
C92.0 |
AURKB; FLT3; |
| C00-D49: Neoplasms |
Acute lymphoblastic leukemia |
C91.0 |
FLT3; |
| K00-K95: Diseases of the digestive system |
Xerostomia |
K11.7, R68.2 |
ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 |
Neurodegenerative disease |
G30-G32 |
ACHE; |
| I00-I99: Diseases of the circulatory system |
Neurological disease |
I21, I22, R52, R52.1-R52.2, R60.9, G89 |
NPSR1; |
| C00-D49: Neoplasms |
Cutaneous Melanoma |
C43-C44 |
KDR; |
| L00-L99: Diseases of the skin and subcutaneous tissue |
Fibrosis |
L90.5 |
MET; |
| C00-D49: Neoplasms |
Metastasis |
C00-C97 |
AXL; |
| C00-D49: Neoplasms |
Myeloid leukemia |
C92 |
FLT3; |
| G00-G99: Diseases of the nervous system G00-G99 |
Myasthenia gravis diagnosis |
G70.0 |
ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 |
Myasthenia gravis |
G70.0 |
ACHE; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Diabetes |
E23.2, N25.1 |
AKR1B1; |
| K00-K95: Diseases of the digestive system |
Ulcerative colitis |
K51 |
MMP9; |
| C00-D49: Neoplasms |
CLL |
NA |
FLT3; |
| G00-G99: Diseases of the nervous system G00-G99 |
Parkinson's disease |
G20 |
ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 |
Pain |
G64, G90.0, R52, G89 |
CDK1; IGF1R; ACHE; |
| A00-B99: Certain infectious and parasitic diseases |
Pediculus humanus capitis |
B85.0 |
ACHE; |
| C00-D49: Neoplasms |
Myelofibrosis |
C94.4, D47.4 |
FLT3; |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Type 2 diabetes |
E11 |
NFKB1; |
| C00-D49: Neoplasms |
Ovarian cancer |
C56 |
KDR; MMP2; |
| C00-D49: Neoplasms |
Prostate cancer |
C61 |
FLT3; |
| L00-L99: Diseases of the skin and subcutaneous tissue |
Psoriasis |
L40 |
FLT3; |
| C00-D49: Neoplasms |
Lung cancer |
C33-C34 |
MMP2; |
| C00-D49: Neoplasms |
Liver cancer |
C22 |
IGF1R; KDR; |
| C00-D49: Neoplasms |
Leukemia |
C90-C95 |
FLT3; |
| K00-K95: Diseases of the digestive system |
Chemotherapy-induced mucositis |
K12.3 |
MET; |
| H00-H59: Diseases of the eye and adnexa |
Chronic glaucoma |
H40-H42 |
ACHE; |
| C00-D49: Neoplasms |
Myelodysplastic syndrome |
D46 |
KDR; |
| L00-L99: Diseases of the skin and subcutaneous tissue |
Psoriatic disorder |
L40 |
IGF1R; |
| K00-K95: Diseases of the digestive system |
Liver disease |
K70-K77 |
MET; |
| H00-H59: Diseases of the eye and adnexa |
Ocular hypertension |
H40.0 |
CA4; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Arthritis |
M00-M25 |
MMP1; |
| C00-D49: Neoplasms |
Non-small cell lung cancer |
C33-C34 |
MET; IGF1R; KDR; AXL; |
| C00-D49: Neoplasms |
Non-small-cell lung cancer |
NA |
KDR; MMP2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Osteoarthritis |
M15-M19, M47 |
MMP2; |
| N00-N99: Diseases of the genitourinary system |
Urinary dysfunction |
N39.3-N39.4 |
ACHE; |
| C00-D49: Neoplasms |
Squamous cell cancer of head and neck |
NA |
KDR; |
| C00-D49: Neoplasms |
Cancer |
C00-C96 |
PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; MMP9; MMP2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Cognitive disorders |
F01-F07, F04, F05, R41.3 |
ACHE; |
| C00-D49: Neoplasms |
Metastatic colorectal cancer |
C18-C21 |
KDR; |
| C00-D49: Neoplasms |
Metastatic castration-resistant prostate cancer |
C61 |
KDR; |
| C00-D49: Neoplasms |
Breast cancer |
C50 |
CDK1; IGF1R; KDR; FLT3; |
| C00-D49: Neoplasms |
Pancreatic cancer |
C25 |
KDR; FLT3; MMP2; |
| C00-D49: Neoplasms |
Thyroid cancer |
C73 |
KDR; |
| H00-H59: Diseases of the eye and adnexa |
Open-angle glaucoma |
H40-H42 |
CA4; ACHE; |
| C00-D49: Neoplasms |
Metastatic HER2-negative gastric cancer |
NA |
MET; |
| C00-D49: Neoplasms |
Biliary cancer |
C22, C24 |
KDR; |
| A00-B99: Certain infectious and parasitic diseases |
Human immunodeficiency virus infection |
B20-B26 |
FLT3; |
| L00-L99: Diseases of the skin and subcutaneous tissue |
Acne vulgaris |
L70.0 |
MMP2; |
