Plant Name: Taxus yunnanensis
Taxonomic Information:
Plant ID: NPO29841
Plant Latin Name: Taxus yunnanensis
Taxonomy Genus: Taxus
Taxonomy Family: Taxaceae
Plant External Links:
NCBI TaxonomyDB:
147275
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005496; steroid binding | 1.169E-04 | 5.694E-01 | CYP3A4, NPC1 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 6.212E-04 | 9.015E-01 | CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 9.607E-04 | 9.015E-01 | CYP3A4, NPC1 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 1.242E-03 | 9.015E-01 | CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.242E-03 | 9.015E-01 | CYP3A4 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 9.015E-01 | NPC1, RAB9A |
| CC | GO:0016020; membrane | GO:0016020; membrane | 2.625E-02 | 1.000E+00 | CYP3A4, NPC1, RAB9A, TDP1 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 2.667E-02 | 1.000E+00 | CYP3A4, NPC1, RAB9A, TDP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 2.241E-02 | CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 9.169E-03 | 2.241E-02 | CYP3A4 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.155E-02 | 2.241E-02 | CYP3A4 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.294E-02 | 2.241E-02 | CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 2.241E-02 | CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.452E-02 | 2.241E-02 | CYP3A4 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 2.241E-02 | CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.630E-02 | 2.241E-02 | CYP3A4 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.693E-02 | 2.962E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.438E-02 | 2.962E-02 | NPC1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
