CMAUP Plant Collective Molecular Activities

Plant Name: Spinulum annotinum

Taxonomic Information:

Plant ID: NPO29658
Plant Latin Name: Spinulum annotinum
Taxonomy Genus: Dendrolycopodium
Taxonomy Family: Lycopodiaceae

Plant External Links:

NCBI TaxonomyDB: 62333
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Finland

Traditional Medicine System:

Geographical Distribution:

Finland

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA14; CA7; CA4;
Oxidoreductase	TYR;
Enzyme_unclassified	ALOX12; HSD17B2; HSD17B10; NOX4; POLB;
Transcription Factor	AHR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.653E-12	1.231E-07	CA12, CA14, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.996E-09	1.087E-05	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.051E-07	2.543E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.011E-07	3.321E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.639E-07	3.321E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.041E-06	8.719E-04	AXL, CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.668E-06	1.248E-03	CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, FLT3, NOX4, TYR
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.209E-06	1.503E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.874E-06	1.711E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.936E-06	1.711E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.936E-06	1.711E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	3.714E-06	1.940E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	2.146E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	7.997E-06	3.225E-03	ALOX12, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, TYR
BP	GO:0032502; developmental process	GO:0007568; aging	8.270E-06	3.274E-03	AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.864E-06	3.386E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0020037; heme binding	1.764E-05	5.909E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	1.964E-05	6.383E-03	AXL, CA2, CYP1A1, CYP1A2, FLT3, HSD17B2, TYR
CC	GO:0016020; membrane	GO:0016020; membrane	2.332E-05	7.360E-03	ALOX12, AXL, CA12, CA14, CA2, CA4, CDK1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B10, HSD17B2, IGF1R, KDR, MET, NOX4, NPSR1, PIM1, TYR
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	3.095E-05	9.361E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.775E-12	6.353E-10	CA12, CA2, CA4, CA7, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.539E-07	1.150E-05	HSD17B2, CYP1A1, CYP1B1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6.478E-07	1.404E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.457E-05	2.367E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.936E-05	1.162E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.263E-04	1.369E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	3.193E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases