CMAUP Plant Collective Molecular Activities

Plant Name: Laurus nobilis

Taxonomic Information:

Plant ID: NPO29515
Plant Latin Name: Laurus nobilis
Taxonomy Genus: Laurus
Taxonomy Family: Lauraceae

Plant External Links:

NCBI TaxonomyDB: 85223
Plant-of-the-World-Online: 465049-1

Used in Medicines:

Country/Region:

Turkey; Afghanistan; Israel; Italy; Tunisia; Lebanon; India; United States; Jordan; Chile; Greece; China; Argentina; Iraq; Spain

Traditional Medicine System:

Indian Folk; TCM; Unani

Medicinal Functions:

Abortifacient; Antirheumatic; Antiseptic; Appetizer; Aromatic; Astringent; Cancer; Carminative; Diaphoretic; Digestive; Diuretic; Emetic; Emmenagogue; Narcotic; Parasiticide; Stimulant; Stomachic

Geographical Distribution:

Turkey; Afghanistan; Italy; India; France; Argentina; Israel; Algeria; China; Chile; Jordan; Iraq; Spain; Libya; United States; Morocco; Albania; Portugal; South Africa; Tunisia; Lebanon; Greece

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nicotinic acetylcholine receptor	CHRNA3; CHRNA4;
Enzyme_unclassified	ALOX15;
Oxidoreductase	PTGS1;
Unclassified	MCL1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nicotinic acetylcholine receptor	CHRNA3	Neuronal acetylcholine receptor subunit alpha-3	P32297	CHEMBL3068
Nicotinic acetylcholine receptor	CHRNA4	Neuronal acetylcholine receptor protein alpha-4 subunit	P43681	CHEMBL1882
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	3.149E-06	6.857E-02	CHRNA3, CHRNA4
MF	GO:0060089; molecular transducer activity	GO:0015464; acetylcholine receptor activity	2.289E-05	7.956E-02	CHRNA3, CHRNA4
BP	GO:0050896; response to stimulus	GO:0095500; acetylcholine receptor signaling pathway	3.781E-05	8.233E-02	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	5.241E-05	9.511E-02	CHRNA3, CHRNA4
BP	GO:0008152; metabolic process	GO:0006636; unsaturated fatty acid biosynthetic process	6.060E-05	1.015E-01	ALOX15, PTGS1
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	9.924E-05	1.544E-01	ALOX15, PTGS1
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	2.125E-04	2.435E-01	ALOX15, PTGS1
BP	GO:0065007; biological regulation	GO:0060078; regulation of postsynaptic membrane potential	4.324E-04	2.853E-01	CHRNA3, CHRNA4
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	2.483E-03	5.198E-01	MCL1
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	3.184E-03	6.361E-01	CHRNA3, CHRNA4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.654E-05	1.300E-03	ALOX15, CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.398E-04	1.504E-03	CHRNA3, CHRNA4, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.133E-04	1.504E-03	TSHR, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.616E-04	1.504E-03	ALOX15, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	8.363E-04	3.263E-03	CHRNA3, CHRNA4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.513E-04	3.263E-03	ALOX15, PTGS1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.049E-02	3.448E-02	ALOX15, CYP3A4, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.727E-02	4.145E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.297E-02	4.145E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.883E-02	4.145E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases