CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	MAPKAPK5; PRKCD; MAPKAPK2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	GMNN;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MAPKAPK5	MAP kinase-activated protein kinase 5	Q8IW41	CHEMBL3094
Protein Kinase	PRKCD	Protein kinase C delta	Q05655	CHEMBL2996
Protein Kinase	MAPKAPK2	MAP kinase-activated protein kinase 2	P49137	CHEMBL2208
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	1.201E-05	8.495E-02	MAPKAPK2, MAPKAPK5, PRKCD
BP	GO:0009987; cellular process	GO:0090398; cellular senescence	3.972E-05	8.649E-02	MAPKAPK5, PRKCD
BP	GO:0065007; biological regulation	GO:0032147; activation of protein kinase activity	8.206E-05	1.289E-01	MAPKAPK2, MAPKAPK5, PRKCD
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	4.855E-04	1.788E-01	GMNN, MAPKAPK2, MAPKAPK5, NR1H4, PRKCD
CC	GO:0044464; cell part	GO:0005737; cytoplasm	2.269E-03	3.555E-01	GMNN, MAPKAPK2, MAPKAPK5, NPSR1, PRKCD
CC	GO:0044464; cell part	GO:0035578; azurophil granule lumen	2.794E-02	1.000E+00	PRKCD
CC	GO:0044464; cell part	GO:0005829; cytosol	3.785E-02	1.000E+00	GMNN, MAPKAPK2, MAPKAPK5, PRKCD
MF	GO:0003824; catalytic activity	GO:0009931; calcium-dependent protein serine/threonine kinase activity	4.417E-06	5.770E-02	MAPKAPK2, MAPKAPK5
MF	Unclassified;	GO:0004871; signal transducer activity	8.023E-04	2.142E-01	MAPKAPK2, MAPKAPK5, NPSR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004699; calcium-independent protein kinase C activity	9.316E-04	2.142E-01	PRKCD

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.348E-03	1.761E-02	MAPKAPK2, MAPKAPK5
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	5.272E-04	7.907E-03	MAPKAPK2, PRKCD
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	2.699E-02	4.399E-02	PRKCD
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.905E-02	4.399E-02	PRKCD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.111E-02	4.399E-02	NR1H4
09150 Organismal Systems	09151 Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2.758E-02	4.399E-02	PRKCD
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	2.934E-02	4.399E-02	PRKCD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	1.432E-02	4.399E-02	PRKCD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.992E-02	4.399E-02	PRKCD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.226E-02	4.399E-02	PRKCD

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Maytenus horrida

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities