CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	CDA; TK1; AKR1B10; AKR1B1; ALOX15;
Transient receptor potential channel	TRPA1;
Lyase	CA12; CA9;
Oxidoreductase	PTGS1; XDH;
Cysteine protease	CASP1; CASP7;
Transcription Factor	HIF1A;
SLC superfamily of solute carriers	SLC28A1; SLC28A3;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP1A2; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.008E-15	1.961E-10	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.512E-10	2.337E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	7.512E-10	2.337E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.442E-09	5.765E-06	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.057E-08	1.129E-05	AKR1B1, AKR1B10, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	1.369E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	1.138E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	2.512E-06	1.436E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	4.066E-06	1.967E-03	SLC28A1, SLC28A3
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	4.066E-06	1.967E-03	CYP2D6, CYP3A4

Showing 1 to 10 of 21 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.472E-10	7.510E-09	CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.352E-08	3.448E-07	CYP2C9, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.100E-07	2.142E-06	CDA, TK1, CYP3A4, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.092E-07	6.028E-06	CYP2C9, ALOX15, CYP2C19, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.372E-06	9.997E-06	CYP2C9, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.539E-05	2.825E-04	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.080E-03	5.893E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7.783E-04	2.835E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.396E-04	2.293E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.011E-03	5.893E-03	CYP1A2, CYP3A4

Showing 1 to 10 of 19 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Prostate cancer	C61	TK1;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CDA; CA9;
C00-D49: Neoplasms	Cancer	C00-C96	TK1; CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cranfillia vulcanica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities