Plant Name: Nekemias grossedentata
Taxonomic Information:
Plant ID: NPO29193
Plant Latin Name: Nekemias grossedentata
Taxonomy Genus: Nekemias
Taxonomy Family: Vitaceae
Plant External Links:
NCBI TaxonomyDB:
416090
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| GAA; | |
| BLM; HSD17B10; ALOX15; | |
| PIM1; CSNK2A1; | |
| PPARA; PPARD; | |
| ESR1; ESR2; | |
| ELANE; | |
| TLR2; | |
| HIF1A; | |
| LMNA; FABP3; FABP5; FABP2; FABP4; MAPT; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.900E-08 | 8.275E-05 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 1.553E-07 | 3.758E-04 | ALOX15, BLM, CYP2C9, CYP3A4, ESR1, ESR2, L3MBTL1, PIM1, PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 1.356E-06 | 1.284E-03 | ESR1, ESR2 |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.699E-06 | 1.480E-03 | ESR1, ESR2, PIM1, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0050727; regulation of inflammatory response | 4.777E-06 | 3.250E-03 | ELANE, ESR1, FABP4, PPARA, PPARD, TLR2 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 7.151E-06 | 4.316E-03 | CSNK2A1, HIF1A, MAPT |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 8.126E-06 | 4.316E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 8.126E-06 | 4.316E-03 | CYP2C9, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.571E-05 | 6.939E-03 | ESR1, ESR2, PPARA, PPARD |
| BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 1.624E-05 | 6.939E-03 | ALOX15, CSNK2A1, ESR1, FABP5, GAA, HIF1A, L3MBTL1, LMNA, PIM1, PPARA, PPARD, TLR2, TSHR |
| BP | GO:0008152; metabolic process | GO:0031328; positive regulation of cellular biosynthetic process | 1.625E-05 | 6.939E-03 | BLM, ELANE, ESR1, ESR2, FABP3, HIF1A, PPARA, PPARD, TLR2, TSHR |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.028E-05 | 8.180E-03 | CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 2.192E-05 | 8.373E-03 | ALOX15, CYP2C9, FABP3, PPARA, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.301E-10 | 9.499E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.760E-06 | 1.738E-04 | CYP2C9, ALOX15, CYP3A4 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.571E-03 | 2.309E-02 | HIF1A, ESR1, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.943E-03 | 2.309E-02 | PIM1, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.876E-03 | 2.309E-02 | FABP4, TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.294E-03 | 2.309E-02 | CYP2C9, ALOX15 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 3.079E-03 | 2.309E-02 | ESR1, ESR2 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.518E-03 | 2.309E-02 | CYP2C9, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.832E-03 | 2.309E-02 | CYP2C9, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.164E-03 | 2.309E-02 | CYP2C9, CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
