CMAUP Plant Collective Molecular Activities

Plant Name: Origanum vulgare

Taxonomic Information:

Plant ID: NPO29169
Plant Latin Name: Origanum vulgare
Taxonomy Genus: Origanum
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 39352
Plant-of-the-World-Online: 453395-1

Used in Medicines:

Country/Region:

Brazil; Turkey; Albania; Italy; Turkmenistan; India; Lithuania; China; Chile; Argentina; Spain; Bulgaria

Traditional Medicine System:

Indian Folk; TCM; Unani; Ayurveda

Medicinal Functions:

Antirheumatic; Antiseptic; Antispasmodic; Aromatherapy; Carminative; Cholagogue; Diaphoretic; Emmenagogue; Expectorant; Odontalgic; Parasiticide; Stimulant; Stomachic; Tonic

Geographical Distribution:

Brazil; Afghanistan; Italy; Turkmenistan; Canada; Nepal; Lithuania; France; Ireland; Argentina; Norway; Belarus; Iran; Algeria; Turkey; Venezuela; China; Chile; Belgium; Germany; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Morocco; Sweden; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Portugal; Mexico; Tunisia; Tajikistan; India; United Kingdom; Austria; Greece; Hungary; Taiwan; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Transient receptor potential channel	TRPA1;
Lyase	CA2; CA7; CA4; CA6; CA12; CA1; CA9; CA14;
Enzyme_unclassified	ALOX15; ALDH1A1;
Oxidoreductase	PTGS1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	2.800E-03	CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.870E-06	2.800E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.721E-22	3.748E-18	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.690E-18	5.106E-14	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.746E-16	2.067E-12	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	9.631E-06	1.104E-02	CA1, CA2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.884E-05	3.140E-02	CA2, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	4.991E-05	4.940E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.919E-22	1.377E-20	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.503E-04	2.105E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.406E-04	2.245E-03	ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.103E-03	6.738E-03	ALOX15, PTGS1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	6.738E-03	ALDH1A1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.223E-03	8.893E-03	GAA, ALOX15, ALDH1A1, CYP3A4, PTGS1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.444E-03	6.738E-03	CA2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	1.240E-02	ALOX15, PTGS1
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.139E-02	6.647E-02	CA2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.374E-02	6.647E-02	GAA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases