CMAUP Plant Collective Molecular Activities

Plant Name: Panax ginseng

Taxonomic Information:

Plant ID: NPO29141
Plant Latin Name: Panax ginseng
Taxonomy Genus: Panax
Taxonomy Family: Araliaceae

Plant External Links:

NCBI TaxonomyDB: 4054
Plant-of-the-World-Online: 91472-1

Used in Medicines:

Country/Region:

China; South Korea; India

Traditional Medicine System:

Indian Folk; TCM; Kampo

Medicinal Functions:

Adaptogen; Antianxiety; Anticholesterolemic; Appetizer; Emetic; Expectorant; Hypoglycaemic; Nervine; Tonic

Geographical Distribution:

India; South Korea; China; Russia; South Africa

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA1; FFAR1; FFAR4; ADORA2A; HCAR2;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL; PIK3CA; PIK3CB; ADK; ALOX12; HSD17B2; GFER; HSD17B10; NQO2; ALOX15; NOX4; POLB;
Protein Kinase	MET; FLT3; CDK1; PIM1; AXL; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA1; CA9; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	PTGS2; TYR; PTGS1;
Metallo protease	MMP9; MMP2; MMP1;
Transcription Factor	HIF1A; TP53; NFKB1; AHR;
Unclassified	LMNA; FABP5; FABP3; FABP4;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP1B1; CYP1A1; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.809E-11	8.237E-08	CA1, CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.259E-09	8.842E-07	CA1, CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.152E-09	2.493E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NOX4
MF	GO:0005488; binding	GO:0020037; heme binding	5.715E-09	2.667E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NOX4, PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.862E-09	3.494E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.400E-07	3.812E-05	CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, NR1H4, PPARA, TP53
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.661E-07	1.340E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.267E-07	1.436E-04	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	9.885E-07	2.174E-04	ADORA1, ADORA2A, ADORA3
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.399E-06	2.902E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.505E-06	3.062E-04	ADORA1, ADORA2A, FFAR4, NFKB1, NR1H4, PPARA
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.362E-06	4.358E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	2.570E-06	4.664E-04	ALOX12, CDC25B, CDK1, ESR1, FLT3, HIF1A, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2, TSHR
MF	Unclassified;	GO:0004872; receptor activity	3.147E-06	5.482E-04	ADORA1, ADORA2A, ADORA3, AHR, AXL, ESR1, FFAR1, FFAR4, FLT3, HCAR2, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, TSHR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.367E-06	5.772E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0043560; insulin receptor substrate binding	4.619E-06	7.678E-04	IGF1R, PIK3CA, PIK3CB
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	5.089E-06	8.360E-04	CA2, CA9, CYP1A2, ESR1, FABP3, FFAR4, FLT3, NFKB1, PPARA, PTGS2, TSHR
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.145E-06	9.697E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0032502; developmental process	GO:0007568; aging	7.198E-06	1.074E-03	AURKB, CDK1, CYP1A1, NOX4, POLB, PTGS2, TP53
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	7.971E-06	1.181E-03	ADORA2A, CA2, CA7
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.488E-06	1.333E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	9.488E-06	1.333E-03	PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.488E-06	1.333E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:1901652; response to peptide	1.183E-05	1.610E-03	FABP3, FFAR4, IGF1R, NFKB1, PPARA, PTGS2, TP53, TSHR
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	1.550E-05	2.046E-03	ALOX12, ALOX15, PTGS2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.605E-05	2.091E-03	AHR, ESR1, NR1H4, PPARA
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.925E-05	2.452E-03	ADORA3, ALOX15, CDK1, CYP1A1, PPARA, TP53
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.841E-05	3.273E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.841E-05	3.273E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	2.841E-05	3.273E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.841E-05	3.273E-03	CYP1A1, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.841E-05	3.273E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.841E-05	3.273E-03	ALOX12, ALOX15
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	2.841E-05	3.273E-03	ADORA1, ADORA2A
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	2.878E-05	3.281E-03	IGF1R, MMP2, NFKB1, NOX4, NR1H4, PTGS2, TP53, TSHR
BP	GO:0009987; cellular process	GO:0055082; cellular chemical homeostasis	3.021E-05	3.419E-03	CA2, CA7, ESR1, HIF1A, NOX4, NPSR1, NR1H4, PIK3CA, PIK3CB, TP53
MF	GO:0005488; binding	GO:0001223; transcription coactivator binding	3.128E-05	3.475E-03	AHR, ESR1, PPARA
BP	GO:0051179; localization	GO:0006909; phagocytosis	3.601E-05	3.901E-03	ADORA1, ADORA2A, ALOX15, AXL
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	3.642E-05	3.906E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.642E-05	3.906E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0023052; signaling	GO:0046887; positive regulation of hormone secretion	4.302E-05	4.398E-03	ADORA2A, FFAR1, HCAR2, HIF1A, NR1H4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	4.475E-05	4.532E-03	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.828E-05	4.867E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	5.670E-05	5.392E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.670E-05	5.392E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.242E-05	5.809E-03	FABP3, FABP4, FABP5
BP	GO:0009987; cellular process	GO:0048010; vascular endothelial growth factor receptor signaling pathway	7.390E-05	6.649E-03	AXL, KDR, PIK3CA, PIK3CB
BP	GO:0065007; biological regulation	GO:0043433; negative regulation of DNA binding transcription factor activity	7.635E-05	6.815E-03	ADORA3, CYP1B1, ESR1, NR1H4, PIM1
BP	GO:0032501; multicellular organismal process	GO:0010575; positive regulation of vascular endothelial growth factor production	7.903E-05	6.996E-03	CYP1B1, HIF1A, PTGS2
BP	GO:0050896; response to stimulus	GO:0014074; response to purine-containing compound	9.003E-05	7.719E-03	ADORA2A, NOX4, PTGS2, TP53, TYR
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.432E-05	7.991E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	9.432E-05	7.991E-03	CYP1A1, CYP3A4
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.041E-04	8.616E-03	CYP1A1, CYP1B1, ESR1, FLT3, NFKB1, NOX4, PTGS2
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.089E-04	8.946E-03	AXL, MET, NOX4, PIK3CA, PIK3CB
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.115E-04	9.028E-03	FABP3, FFAR1, NR1H4, PTGS2
BP	GO:0008152; metabolic process	GO:0045833; negative regulation of lipid metabolic process	1.115E-04	9.028E-03	ADORA1, HCAR2, NFKB1, NR1H4
BP	GO:0032502; developmental process	GO:0045766; positive regulation of angiogenesis	1.158E-04	9.302E-03	ALOX12, CYP1B1, HIF1A, KDR, PTGS2
BP	GO:0008152; metabolic process	GO:0032963; collagen metabolic process	1.170E-04	9.370E-03	HIF1A, MMP1, MMP2, MMP9
BP	GO:0050896; response to stimulus	GO:0033273; response to vitamin	1.228E-04	9.616E-03	CYP1A1, PTGS2, TP53, TYR
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.226E-14	8.899E-11	CA1, CA12, CA14, CA2, CA4, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.893E-14	4.512E-12	CA12, CA1, CA2, CA4, CA7, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.507E-10	2.344E-08	PIK3CA, MMP2, KDR, PIK3CB, TP53, HIF1A, ESR1, MMP9, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.151E-10	2.344E-08	FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, TSHR, PTGS1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.880E-09	7.332E-08	PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, HIF1A, MET, TP53, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	4.883E-08	1.524E-06	PIK3CA, FLT3, PIK3CB, TP53, MET, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.371E-07	3.565E-06	HCAR2, PIK3CA, ADORA2A, ADORA1, PIK3CB, PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.369E-07	5.279E-06	PIK3CA, PIM1, CYP1B1, PTGS2, TP53, MMP9, MET, NFKB1, CDC25B
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.916E-07	7.636E-06	HSD17B2, CYP1A1, CYP1B1, PTGS2, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	7.615E-07	1.297E-05	PIK3CA, FLT3, PIM1, PIK3CB, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.581E-06	2.242E-05	PIK3CA, ADORA3, ADORA1, PIK3CB, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.293E-06	2.752E-05	PIK3CA, PIK3CB, TP53, MET, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.315E-07	1.297E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.633E-06	2.934E-05	CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.989E-06	2.585E-05	FABP3, FABP4, FABP5, MMP1, PPARA
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	7.015E-06	6.080E-05	PIK3CA, PIK3CB, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	5.927E-06	5.779E-05	PIK3CA, PIK3CB, PTGS2, TP53, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.302E-05	9.236E-05	PIK3CA, MMP2, PIM1, PIK3CB, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	9.172E-06	7.531E-05	PIK3CA, PIK3CB, TP53, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.124E-05	8.770E-05	PIK3CA, CDK1, PIK3CB, CDC25B, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.686E-06	4.874E-05	CYP1A2, CYP1A1, CYP1B1, CYP3A4, PTGS2
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.181E-05	8.777E-05	PIK3CA, MMP2, PIK3CB, ESR1, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.433E-05	9.719E-05	PIK3CA, PIK3CB, HIF1A, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.971E-05	1.230E-04	PIK3CA, PIK3CB, PTGS2, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.636E-05	1.063E-04	FLT3, TP53, MMP9, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	3.404E-05	1.831E-04	POLB, PIK3CA, CDK1, PIK3CB, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.820E-06	6.080E-05	MMP1, MMP2, MMP9, TP53
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.151E-05	1.291E-04	CYP2D6, ALOX15, ALOX12, PTGS2, PTGS1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	4.000E-05	2.013E-04	PIK3CA, ADORA2A, KDR, PIK3CB, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.767E-05	1.599E-04	PIK3CA, PIK3CB, TP53, ESR1, HIF1A
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	6.006E-05	2.603E-04	PIK3CA, KDR, PIK3CB, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	3.361E-05	1.831E-04	PIK3CA, KDR, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	7.003E-05	2.731E-04	PIK3CA, KDR, PIK3CB, TP53, MET, NFKB1, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.271E-05	2.644E-04	PIK3CA, LMNA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	4.912E-05	2.189E-04	PIK3CA, PIK3CB, PPARA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	4.321E-05	2.106E-04	PIK3CA, PIK3CB, TP53, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.653E-05	2.912E-04	PIK3CA, PIK3CB, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	4.590E-05	2.106E-04	PIK3CA, PIK3CB, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.584E-05	1.864E-04	ALOX15, ALOX12, PTGS2, PTGS1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	4.590E-05	2.106E-04	PIK3CA, PIK3CB, MET, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	6.464E-05	2.654E-04	PIK3CA, PIK3CB, ESR1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	3.480E-04	1.180E-03	PIK3CA, CDK1, PIK3CB, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	6.824E-05	2.730E-04	PIK3CA, PIK3CB, TP53, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	3.480E-04	1.180E-03	PIK3CA, KDR, PIK3CB, MET, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.218E-04	1.141E-03	PIK3CA, PIK3CB, PPARA, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	4.637E-04	1.507E-03	PIK3CA, PIK3CB, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.021E-03	2.843E-03	HSD17B2, CYP1A2, ALOX15, CYP1A1, ADK, ALOX12, PTGS2, CYP3A4, TYR, HSD17B10, PTGS1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	7.427E-04	2.272E-03	PIK3CA, PIK3CB, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	4.351E-04	1.444E-03	PIK3CA, MMP2, PIK3CB, MMP9
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	1.053E-03	2.881E-03	POLB, PIK3CA, PIK3CB, TP53, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	1.096E-03	2.949E-03	PIK3CA, PIK3CB, PPARA, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	1.589E-03	3.999E-03	PIK3CA, ADORA3, ADORA1, PIK3CB
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.189E-03	7.654E-03	PIK3CA, ALOX12, PIK3CB
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	3.472E-03	8.084E-03	PIK3CA, PIK3CB, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	3.376E-03	7.980E-03	PIK3CA, PIK3CB, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	7.778E-04	2.333E-03	PIK3CA, PIK3CB, HIF1A
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	3.977E-03	8.863E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	6.354E-04	1.983E-03	PIK3CA, PIK3CB, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	3.770E-03	8.524E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09149 Aging	hsa04213	Longevity regulating pathway - multiple species	9.390E-04	2.713E-03	PIK3CA, PIK3CB, IGF1R
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	3.770E-03	8.524E-03	PIK3CA, PIK3CB, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.375E-03	3.517E-03	PIK3CA, PIK3CB, NFKB1
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	8.560E-04	2.519E-03	PIK3CA, PIK3CB, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	5.109E-04	1.627E-03	PIK3CA, PIK3CB, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05100	Bacterial invasion of epithelial cells	1.664E-03	4.121E-03	PIK3CA, PIK3CB, MET
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.823E-04	2.786E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.168E-03	3.089E-03	CYP2D6, CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.269E-03	3.300E-03	CA2, NR1H4, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.343E-04	8.501E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.872E-05	3.295E-04	CYP1A2, ALOX15, CYP3A4
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.150E-03	5.241E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
NA: NA	Gonorrheal vaginitis	NA	ESR1;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
NA: NA	GIST	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3; PTGS2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; CA2;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; PIK3CA; KDR; FLT3; HIF1A; MMP9; PIK3CB; TP53; MMP2; CA9;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1;
NA: NA	Joint and muscular pain	NA	PTGS2;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; PTGS2; MMP2;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; CDK1; IGF1R; KDR; FLT3; NQO2; CA9;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3; CA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6; ADORA3;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1; FFAR1;
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR; HCAR2;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; IGF1R;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1;
NA: NA	Rheumatold arthritis	NA	PTGS1; PTGS2;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; PIM1; MET; CDK1; IGF1R; PIK3CA; KDR; NFKB1; FLT3; HIF1A; ADORA3; MMP9; PTGS2; PIK3CB; NQO2; TP53; MMP2; CDC25B; CA1; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; PTGS2; HCAR2; FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; PTGS2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; NPSR1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; PTGS2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9; PTGS1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A; PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; MMP1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A; HCAR2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1; ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; PTGS2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9; PTGS1; TP53;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A; PTGS1; PTGS2;
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; MMP1; TYR;
C00-D49: Neoplasms	Glioma	C71	KDR;
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1; PTGS2; MMP2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; PTGS1; MMP2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1;
NA: NA	Miosis during ocular surgery	NA	PTGS1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; CDK1; IGF1R; ADORA2A; ADK; PTGS1; PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ADORA1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1; ADORA1; HCAR2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1;
NA: NA	Postmenopausal disorder	NA	ESR1;
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1;
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	PIK3CB;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1;
NA: NA	Menopausal disorder	NA	ESR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	HIV infections	NA	AHR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1; PTGS1; PTGS2;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	PIK3CA; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases