CMAUP Plant Collective Molecular Activities

Plant Name: Litsea cubeba

Taxonomic Information:

Plant ID: NPO29110
Plant Latin Name: Litsea cubeba
Taxonomy Genus: Litsea
Taxonomy Family: Lauraceae

Plant External Links:

NCBI TaxonomyDB: 155299
Plant-of-the-World-Online: 465621-1

Used in Medicines:

Country/Region:

China; Indonesia; India

Traditional Medicine System:

Indian Folk; TCM; Ayurveda

Medicinal Functions:

Antiphlogistic; Expectorant

Geographical Distribution:

Nepal; Bangladesh; Myanmar; Indonesia; India; Cambodia; Vietnam; China; Laos; Japan; Taiwan; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR5A; HTR2B; DRD1; HTR6; HTR1A;
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Enzyme_unclassified	ALOX15; ALDH1A1;
Lysine demethylase	KDM4E;
Transcription Factor	HIF1A;
Unclassified	MAPT; HTT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP1A2; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	1.609E-11	8.758E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	1.609E-11	8.758E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0005488; binding	GO:0051378; serotonin binding	1.734E-10	5.864E-07	HTR1A, HTR2B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	2.716E-09	5.915E-06	HTR1A, HTR5A, HTR7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.357E-08	2.272E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.487E-07	2.024E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.189E-06	1.295E-03	CYP1A2, CYP2D6, CYP3A4
BP	Unclassified;	GO:0042310; vasoconstriction	2.445E-06	2.142E-03	HTR1A, HTR2B, HTR7
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.459E-06	2.142E-03	CYP2D6, CYP3A4
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	4.617E-06	3.345E-03	DRD1, HTR1A, HTR2B, HTR7
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.916E-06	3.345E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	9.408E-06	5.537E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.267E-05	6.731E-03	ALOX15, CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.636E-05	8.096E-03	ALOX15, CYP1A2, CYP2D6
CC	GO:0044464; cell part	GO:0042995; cell projection	1.588E-05	8.096E-03	DRD1, HIF1A, HTR2B, HTR5A, HTR6, HTT, MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	3.136E-05	1.366E-02	HIF1A, MAPK1, MAPT
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.682E-04	3.488E-02	DRD1, HTR1A, HTR2B, HTR5A, HTR6, HTR7, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.133E-14	3.572E-12	HTR6, HTR7, CYP2D6, ALOX15, HTR1A, HTR2B, MAPK1, HTR5A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.532E-09	1.443E-07	HTR6, HTR7, HTR1A, HTR2B, DRD1, HTR5A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	4.352E-07	1.654E-05	HTR6, HTR7, HTR2B, DRD1, HTR5A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.152E-07	2.038E-05	HTR6, HTR1A, MAPK1, DRD1, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.204E-06	5.025E-05	CYP1A2, ALOX15, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.582E-05	4.906E-04	CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.090E-05	5.032E-04	CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.660E-05	5.215E-04	CYP2D6, CYP1A2, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	6.403E-05	8.111E-04	HTR2B, MAPK1, DRD1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.227E-03	1.361E-02	CYP1A2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B;
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
NA: NA	Cervical dystonia	NA	HTR1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
NA: NA	Social phobia	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
NA: NA	Bulimia nervosa	NA	HTR1A;
NA: NA	Schizoaffective disorder	NA	HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR6; MAPT; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD1; HTR6; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2B; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6;
NA: NA	Peripheral sensory neuropathies	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; HTR1A;
NA: NA	Episode	NA	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2B; HTR1A;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B;
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A;
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A;
NA: NA	Anxiety disorders	NA	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR6; HTR1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6; MAPT;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1; HTR6;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; HTR6; MAPT; HTR1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; HTR1A;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1; HTR1A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases