Plant Name: Clausena anisata
Taxonomic Information:
Plant ID: NPO29109
Plant Latin Name: Clausena anisata
Taxonomy Genus: Clausena
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
159034
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Togo; Kenya; Tanzania; Rwanda; South AfricaTraditional Medicine System:
Geographical Distribution:
Togo; Kenya; Tanzania; Rwanda; South Africa
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| TP53; | |
| LMNA; XPO1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | XPO1 | Exportin-1 | O14980 | CHEMBL5661 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0046825; regulation of protein export from nucleus | 1.592E-05 | 3.457E-01 | TP53, XPO1 |
| BP | GO:0051179; localization | GO:1903827; regulation of cellular protein localization | 1.212E-04 | 4.509E-01 | LMNA, TP53, XPO1 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.711E-04 | 4.509E-01 | LMNA, TP53 |
| CC | GO:0043226; organelle | GO:0016604; nuclear body | 1.957E-04 | 4.509E-01 | LMNA, TP53, XPO1 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 4.813E-01 | TSHR |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.449E-03 | 6.713E-01 | TP53 |
| MF | GO:0005488; binding | GO:0035035; histone acetyltransferase binding | 5.580E-03 | 9.524E-01 | TP53 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 5.786E-03 | 9.524E-01 | TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.892E-04 | 1.359E-02 | LMNA, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 6.010E-04 | 1.412E-02 | XPO1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 9.777E-04 | 1.532E-02 | XPO1, TP53 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 1.373E-02 | 3.361E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.768E-02 | 3.361E-02 | TP53 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03008 | Ribosome biogenesis in eukaryotes | 1.768E-02 | 3.361E-02 | XPO1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.709E-02 | 3.361E-02 | TP53 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.361E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.361E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.361E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
