CMAUP Plant Collective Molecular Activities

Plant Name: Meconopsis punicea

Taxonomic Information:

Plant ID: NPO29105
Plant Latin Name: Meconopsis punicea
Taxonomy Genus: Meconopsis
Taxonomy Family: Papaveraceae

Plant External Links:

NCBI TaxonomyDB: 248846
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	GAA;
Nicotinic acetylcholine receptor	CHRNA3; CHRNA4;
Enzyme_unclassified	POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nicotinic acetylcholine receptor	CHRNA3	Neuronal acetylcholine receptor subunit alpha-3	P32297	CHEMBL3068
Nicotinic acetylcholine receptor	CHRNA4	Neuronal acetylcholine receptor protein alpha-4 subunit	P43681	CHEMBL1882
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0035095; behavioral response to nicotine	1.687E-06	3.674E-02	CHRNA3, CHRNA4
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	1.533E-05	4.015E-02	CHRNA3, CHRNA4, GAA
BP	GO:0050896; response to stimulus	GO:0095500; acetylcholine receptor signaling pathway	2.028E-05	4.015E-02	CHRNA3, CHRNA4
MF	GO:0060089; molecular transducer activity	GO:0015464; acetylcholine receptor activity	1.228E-05	4.015E-02	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	2.813E-05	4.711E-02	CHRNA3, CHRNA4
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	1.869E-04	1.947E-01	CHRNA3, CHRNA4
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.731E-03	5.234E-01	CHRNA3, CHRNA4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.097E-05	1.121E-03	CHRNA3, CHRNA4, TSHR
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	4.513E-04	4.964E-03	CHRNA3, CHRNA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.670E-03	2.984E-02	CYP1A2
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	1.194E-02	2.984E-02	CHRNA4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.967E-03	2.984E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.668E-02	2.984E-02	GAA
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.668E-02	2.984E-02	TSHR
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.580E-02	2.984E-02	TSHR
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	9.860E-03	2.984E-02	POLB
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.499E-03	1.099E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CHRNA3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRNA3;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases