CMAUP Plant Collective Molecular Activities

Plant Name: Tinospora hainanensis

Taxonomic Information:

Plant ID: NPO2905
Plant Latin Name: Tinospora hainanensis
Taxonomy Genus: Tinospora
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	GAA;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLCO1B1; SLCO1B3;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.398E-09	3.044E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.536E-08	1.672E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.155E-07	3.016E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	9.828E-07	4.200E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.157E-06	4.200E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.667E-06	2.293E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.271E-05	2.682E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.639E-05	2.745E-02	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.319E-05	3.350E-02	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	2.615E-05	3.350E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.034E-05	4.261E-02	CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	7.249E-05	6.577E-02	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.176E-03	7.627E-01	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.210E-03	8.987E-01	CYP2C19, CYP2C9, CYP3A4, GAA, LMNA
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	7.311E-03	1.000E+00	CYP2C19, CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.289E-07	1.213E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.253E-06	6.266E-05	CYP2C9, CYP3A4, CYP2C19
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.547E-06	6.266E-05	SLCO1B1, SLCO1B3, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.482E-06	7.263E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.357E-04	3.259E-03	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.690E-04	3.259E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.653E-04	3.523E-03	CYP2C9, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.436E-03	8.454E-03	CYP2C9, GAA, CYP2C19, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.091E-03	7.225E-03	CYP2C9, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.696E-03	8.989E-03	LMNA, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases