Plant Name: Vincetoxicum atratum
Taxonomic Information:
Plant ID: NPO29042
Plant Latin Name: Vincetoxicum atratum
Taxonomy Genus: Vincetoxicum
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
157443
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| CA2; CA3; CA14; CA7; CA5A; CA6; CA12; CA9; CA1; | |
| PPARA; PPARD; | |
| TLR2; | |
| NFKB1; | |
| FABP3; LMNA; FABP4; FABP5; FABP2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.081E-09 | 1.961E-06 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, PPARA, PPARD |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 8.346E-09 | 1.136E-05 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.478E-25 | 9.751E-21 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.748E-06 | 1.931E-03 | CA2, CA7 |
| BP | GO:0050896; response to stimulus | GO:0043434; response to peptide hormone | 5.871E-06 | 3.551E-03 | FABP3, NFKB1, PPARA, TLR2, TSHR |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 1.372E-05 | 8.073E-03 | CA1, CA2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.257E-20 | 6.813E-16 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.698E-18 | 2.558E-14 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 5.015E-05 | 2.324E-02 | FABP3, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.589E-24 | 1.160E-22 | CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 3.535E-11 | 1.290E-09 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 8.360E-04 | 1.609E-02 | PPARA, NFKB1, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.323E-03 | 1.609E-02 | NFKB1, PPARD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.232E-03 | 1.609E-02 | NFKB1, TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.277E-03 | 1.609E-02 | FABP4, TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 1.716E-03 | 1.751E-02 | NFKB1, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 2.159E-03 | 1.751E-02 | NFKB1, TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.987E-03 | 1.751E-02 | PPARA, NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 4.737E-03 | 2.660E-02 | PPARA, NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
