CMAUP Plant Collective Molecular Activities

Plant Name: Zanthoxylum americanum

Taxonomic Information:

Plant ID: NPO29030
Plant Latin Name: Zanthoxylum americanum
Taxonomy Genus: Zanthoxylum
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 354526
Plant-of-the-World-Online: 775568-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

TCM

Medicinal Functions:

Anodyne; Antirheumatic; Antispasmodic; Carminative; Diaphoretic; Diuretic; Irritant; Odontalgic; Sialagogue; Skin; Stimulant

Geographical Distribution:

United States; India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AMY1A;AMY1B;AMY1C;
Isomerase	TOP1;
Lyase	CA1; CA7; CA12; CA9; CA13;
Serine protease	F10;
Aspartic protease	BACE1;
Unclassified	RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Isomerase	TOP1	DNA topoisomerase I	P11387	CHEMBL1781
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Serine protease	F10	Coagulation factor X	P00742	CHEMBL244
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.720E-13	3.745E-09	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.143E-11	2.334E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.157E-11	4.469E-07	CA1, CA12, CA13, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	2.380E-09	7.402E-06	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	2.380E-09	7.402E-06	AMY1A, AMY1B, AMY1C
BP	GO:0032501; multicellular organismal process	GO:0007586; digestion	1.502E-05	2.725E-02	AMY1A, AMY1B, AMY1C

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.976E-13	2.678E-12	CA12, CA1, CA7, CA9, CA13
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5.830E-06	1.749E-05	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.997E-06	1.348E-05	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	2.359E-05	5.308E-05	AMY1A, AMY1B, AMY1C
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.251E-02	7.525E-02	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09151 Immune system	hsa04610	Complement and coagulation cascades	5.017E-02	7.525E-02	F10
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	7.709E-02	9.552E-02	NPC1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	8.491E-02	9.552E-02	RAB9A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.039E-01	1.039E-01	BACE1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Deep venous clots	I80.2	F10;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	TOP1;
I00-I99: Diseases of the circulatory system	Deep vein thrombosis	I80-I82, I80.2	F10;
C00-D49: Neoplasms	Metastatic breast cancer	C50	TOP1;
C00-D49: Neoplasms	Gastric cancer	C16	TOP1;
I00-I99: Diseases of the circulatory system	Venous thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Venous thrombosis	I80-I82	F10;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	TOP1;
C00-D49: Neoplasms	Bladder cancer	C67	TOP1;
C00-D49: Neoplasms	Lung cancer	C33-C34	TOP1;
C00-D49: Neoplasms	Advanced ovarian cancer	NA	TOP1;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TOP1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10;
C00-D49: Neoplasms	Ovarian cancer	C56	TOP1;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	TOP1;
I00-I99: Diseases of the circulatory system	Prophylaxis of deep vein thrombosis	I80-I82, I80.2	F10;
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10;
C00-D49: Neoplasms	Renal cancer	C64	F10; CA9;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TOP1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F10;
C00-D49: Neoplasms	Breast cancer	C50	TOP1; CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	TOP1; CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP1; CA9;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	F10;
NA: NA	Christmas disease	NA	F10;
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	TOP1;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	F10;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TOP1;
C00-D49: Neoplasms	Esophageal cancer	C15	TOP1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10;
NA: NA	Haemophilia B	NA	F10;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	F10;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases