CMAUP Plant Collective Molecular Activities

Plant Name: Khaya grandifoliola

Taxonomic Information:

Plant ID: NPO29027
Plant Latin Name: Khaya grandifoliola
Taxonomy Genus: Khaya
Taxonomy Family: Meliaceae

Plant External Links:

NCBI TaxonomyDB: 859838
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Nigeria

Traditional Medicine System:

Geographical Distribution:

Nigeria

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Enzyme_unclassified	RECQL; ALDH1A1; HSD17B2;
Lyase	CA7; CA4; CA12;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	HIF1A;
Unclassified	NPC1; MAPT; RAB9A; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.357E-08	2.954E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.716E-08	7.312E-04	CYP2C19, CYP2C9, CYP3A4, HSD17B2, NPC1, NR1H4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.487E-07	1.079E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.070E-07	1.671E-03	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.459E-06	6.982E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.459E-06	6.982E-03	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.759E-06	8.234E-03	CA12, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.993E-06	8.234E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.916E-06	8.234E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	9.408E-06	1.366E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	5.383E-05	4.689E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	6.359E-05	4.975E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.130E-07	1.280E-05	CA12, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.204E-06	3.416E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.582E-05	2.395E-04	CYP2C9, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.090E-05	2.395E-04	CYP2C9, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.185E-05	3.215E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.401E-03	6.205E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.227E-03	6.205E-03	HSD17B2, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.932E-03	1.219E-02	CYP2C9, HSD17B2, ALDH1A1, CYP2C19, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.936E-03	6.668E-03	CYP2C9, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.832E-03	6.668E-03	NR1H4, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases