CMAUP Plant Collective Molecular Activities

Plant Name: Coptis teeta

Taxonomic Information:

Plant ID: NPO29008
Plant Latin Name: Coptis teeta
Taxonomy Genus: Coptis
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 261448
Plant-of-the-World-Online: 710326-1

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Unani; Ayurveda; Siddha

Medicinal Functions:

Alterative; Anaesthetic; Analgesic; Antibacterial; Antispasmodic; Febrifuge; Ophthalmic; Pectoral

Geographical Distribution:

India; China; Bangladesh

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2B; CHRM1; DRD1; HTR2B;
Enzyme_unclassified	RECQL; AKR1B10; AKR1B1;
Hydrolase	GAA; BCHE; ACHE;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA5A; CA6;
Transcription Factor	HIF1A;
Unclassified	HTT; LMNA; RAD52; F3; SIGMAR1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP3A4; CYP1A2; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAD52	DNA repair protein RAD52 homolog	P43351	CHEMBL2362978
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.733E-13	9.435E-10	CA1, CA12, CA2, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.056E-10	3.832E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	9.890E-07	1.282E-03	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.890E-07	1.282E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.001E-06	1.282E-03	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.364E-06	1.563E-03	BCHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	2.830E-06	2.117E-03	ACHE, BCHE
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.412E-06	2.397E-03	AKR1B1, AKR1B10, CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway	6.690E-06	3.937E-03	ADRA2B, ADRA2C, DRD1, TSHR
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	8.482E-06	4.104E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	8.482E-06	4.104E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	7.860E-06	4.104E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	8.482E-06	4.104E-03	ADRA2B, ADRA2C
CC	GO:0044464; cell part	GO:0042995; cell projection	1.120E-05	4.910E-03	ADRA2C, AKR1B1, CA2, CHRM1, DRD1, HIF1A, HTR2B, HTT, MAPK1, SMN1, SMN2
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	1.607E-05	5.967E-03	ACHE, CHRM1, SIGMAR1, SMN1, SMN2, TSHR
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.695E-05	5.967E-03	ADRA2B, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.695E-05	5.967E-03	ADRA2B, ADRA2C
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.695E-05	5.967E-03	CYP1A2, CYP3A4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.562E-05	8.327E-03	CA2, CA7, DRD1, HTR2B, HTT
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.622E-05	8.396E-03	CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.847E-19	4.021E-15	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.919E-15	5.355E-11	CA1, CA12, CA14, CA2, CA5A, CA6, CA7, CA9
CC	GO:0044464; cell part	GO:0043005; neuron projection	4.415E-05	1.248E-02	ADRA2C, CA2, CHRM1, HTR2B, HTT, MAPK1, SMN1, SMN2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.848E-04	3.382E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	2.020E-04	3.605E-02	AKR1B1, HIF1A, MAPK1
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.182E-04	3.801E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.270E-19	6.746E-17	CA12, CA1, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.922E-06	2.308E-04	CYP2D6, CYP1A2, CYP3A4, CYP2C19
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.408E-06	2.308E-04	CHRM1, HTR2B, DRD1, ADRA2C, ADRA2B, TSHR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.364E-05	7.177E-04	CYP2D6, HTR2B, MAPK1, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.452E-05	4.126E-04	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.612E-05	4.126E-04	AKR1B10, GAA, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.104E-04	4.717E-03	CHRM1, MAPK1, DRD1, TSHR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.353E-04	4.302E-03	CYP2D6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	8.041E-04	9.356E-03	ACHE, CHRM1, MAPK1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	4.082E-04	5.225E-03	HTR2B, MAPK1, DRD1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.316E-04	4.717E-03	CYP1A2, CYP3A4, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; DRD1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
NA: NA	Upper abdominal bloating	NA	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; DRD1;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; MAPK1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases