CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	NPC1; XBP1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	XBP1	X-box-binding protein 1	P17861	CHEMBL1741176
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0042632; cholesterol homeostasis	3.442E-05	3.747E-01	NPC1, XBP1
BP	GO:0050896; response to stimulus	GO:0009750; response to fructose	1.242E-03	7.310E-01	XBP1
CC	GO:0044464; cell part	GO:0005764; lysosome	5.958E-04	7.310E-01	NPC1, RAB9A
MF	GO:0005488; binding	GO:0005496; steroid binding	1.330E-02	1.000E+00	NPC1
MF	GO:0005488; binding	GO:0001158; enhancer sequence-specific DNA binding	1.422E-02	1.000E+00	XBP1
MF	GO:0005488; binding	GO:0001085; RNA polymerase II transcription factor binding	1.791E-02	1.000E+00	XBP1
MF	GO:0005488; binding	GO:0036094; small molecule binding	4.369E-02	1.000E+00	NPC1, RAB9A

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2.514E-02	3.142E-02	XBP1
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.834E-02	3.142E-02	NPC1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	2.248E-02	3.142E-02	XBP1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.026E-02	3.142E-02	RAB9A
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	3.820E-02	3.820E-02	XBP1

Showing 1 to 5 of 5 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Croton hutchinsonianus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities