Plant Name: Allium fistulosum
Taxonomic Information:
Plant ID: NPO28923
Plant Latin Name: Allium fistulosum
Taxonomy Genus: Allium
Taxonomy Family: Amaryllidaceae
Plant External Links:
NCBI TaxonomyDB:
35875
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Philippines; Indonesia; Malaysia; Vietnam; Thailand; South KoreaTraditional Medicine System:
Medicinal Functions:
Antibacterial; Antifungal; Antipyretic; Diuretic; Expectorant; Stomachic
Geographical Distribution:
Philippines; Indonesia; Malaysia; Vietnam; Thailand; South Korea
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TRPA1; | |
| TERT; | |
| CA1; CA5B; CA5A; CA6; CA12; | |
| CTSL; CTSB; | |
| HTT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CTSL | Cathepsin L | P07711 | CHEMBL3837 |
| Cysteine protease | CTSB | Cathepsin B | P07858 | CHEMBL4072 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.372E-14 | 7.342E-10 | CA1, CA12, CA5A, CA5B, CA6 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.214E-12 | 4.587E-08 | CA1, CA12, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.212E-11 | 8.795E-08 | CA1, CA12, CA5A, CA5B, CA6 |
| CC | GO:0044464; cell part | GO:0036021; endolysosome lumen | 2.410E-06 | 6.561E-03 | CTSB, CTSL |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.756E-05 | 4.616E-02 | CA1, CA12, CA5A, CA5B, CA6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.836E-14 | 6.420E-13 | CA12, CA1, CA5B, CA5A, CA6 |
| 09150 Organismal Systems | 09151 Immune system | hsa04612 | Antigen processing and presentation | 6.453E-04 | 3.549E-03 | CTSL, CTSB |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.110E-03 | 5.803E-03 | CTSL, CTSB |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.635E-03 | 5.803E-03 | CTSL, CTSB |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04924 | Renin secretion | 3.155E-02 | 6.941E-02 | CTSB |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.794E-02 | 7.534E-02 | TRPA1 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05323 | Rheumatoid arthritis | 4.411E-02 | 7.534E-02 | CTSL |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 9.701E-02 | 1.067E-01 | CTSL |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 9.244E-02 | 1.067E-01 | HTT |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04145 | Phagosome | 7.440E-02 | 1.023E-01 | CTSL |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT; |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT; |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT; |
| C00-D49: Neoplasms | Melanoma | C43 | TERT; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT; |
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