CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2;
Hydrolase	GAA; ACHE;
Protein Kinase	MAPK1;
Enzyme_unclassified	ALDH1A1; USP2; POLB;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867

Showing 1 to 10 of 11 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	1.768E-06	9.624E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	1.768E-06	9.624E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	5.048E-06	1.374E-02	ACHE, ADRA2A, ADRA2C, ALDH1A1, CYP3A4
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	5.887E-06	1.424E-02	ADRA2A, ADRA2C, NMUR2
BP	GO:0007610; behavior	GO:0007610; behavior	6.736E-06	1.467E-02	GAA, MAPK1, MAPT, NMUR2, USP2
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	8.842E-07	9.624E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	8.240E-06	1.495E-02	ADRA2A, ADRA2C

Showing 1 to 7 of 7 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.613E-04	1.908E-02	ALDH1A1, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	8.982E-05	9.161E-03	MAPK1, ADRA2C, ADRA2A
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.994E-04	1.908E-02	NMUR2, ADRA2C, ADRA2A
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.625E-03	4.144E-02	ACHE, MAPK1
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	5.575E-02	8.807E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	6.096E-02	8.807E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.992E-02	8.807E-02	MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	3.670E-03	7.488E-02	MAPK1, MAPT
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	5.411E-03	8.807E-02	POLB, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	5.575E-02	8.807E-02	MAPK1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;

Showing 1 to 10 of 22 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Clausena lenis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities