Plant Name: Holocarpha obconica
Taxonomic Information:
Plant ID: NPO28867
Plant Latin Name: Holocarpha obconica
Taxonomy Genus: Holocarpha
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| AMY1A;AMY1B;AMY1C; | |
| TOP1; | |
| BACE1; | |
| F10; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Enzyme_unclassified | AMY1A;AMY1B;AMY1C | Salivary alpha-amylase | P04745 | CHEMBL2478 |
| Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
| Serine protease | F10 | Coagulation factor X | P00742 | CHEMBL244 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0032922; circadian regulation of gene expression | 1.134E-02 | 1.000E+00 | TOP1 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 3.111E-02 | 1.000E+00 | F10 |
| BP | GO:0008152; metabolic process | GO:0006260; DNA replication | 3.273E-02 | 1.000E+00 | TOP1 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 3.374E-02 | 1.000E+00 | TOP1 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 2.360E-02 | 1.000E+00 | TOP1 |
| MF | GO:0005488; binding | GO:0001540; amyloid-beta binding | 1.237E-02 | 1.000E+00 | BACE1 |
| MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 2.299E-02 | 1.000E+00 | TOP1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09151 Immune system | hsa04610 | Complement and coagulation cascades | 1.571E-02 | 3.142E-02 | F10 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.318E-02 | 3.318E-02 | BACE1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Renal cancer | C64 | F10; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | TOP1; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Blood coagulation disorders | D65-D68 | F10; |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F10; |
| C00-D49: Neoplasms | Bladder cancer | C67 | TOP1; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TOP1; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | TOP1; |
| I00-I99: Diseases of the circulatory system | Coagulation | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Deep vein thrombosis | I80-I82, I80.2 | F10; |
| NA: NA | Christmas disease | NA | F10; |
| I00-I99: Diseases of the circulatory system | Deep venous clots | I80.2 | F10; |
| NA: NA | Haemophilia B | NA | F10; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | F10; |
| C00-D49: Neoplasms | Esophageal cancer | C15 | TOP1; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | TOP1; |
| I00-I99: Diseases of the circulatory system | Thromboembolic disorders | I80-I82 | F10; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | F10; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | TOP1; |
| C00-D49: Neoplasms | Advanced ovarian cancer | NA | TOP1; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TOP1; |
| I00-I99: Diseases of the circulatory system | Acute coronary syndrome | I74 | F10; |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | TOP1; |
| I00-I99: Diseases of the circulatory system | Venous thrombosis | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Venous thromboembolism | I80-I82 | F10; |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | TOP1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | F10; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TOP1; |
| I00-I99: Diseases of the circulatory system | Prophylaxis of deep vein thrombosis | I80-I82, I80.2 | F10; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TOP1; |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | F10; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | F10; |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | F10; |
| C00-D49: Neoplasms | Gastric cancer | C16 | TOP1; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TOP1; |
| C00-D49: Neoplasms | Breast cancer | C50 | TOP1; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hematology | D50-D77 | F10; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Hemophilia | D66-D68 | F10; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TOP1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
